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NCT01762943 · ClinicalTrials.gov registry record · NA
Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 36
- Enrollment target
NCT01762943: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT01762943 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 36 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01762943, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 36 participants
- Enrollment target
Study Summary
Understanding the neural and biological mechanisms by which reproductive hormones influence mood is critically important for public health given that postpartum depression (PPD) is the leading cause of morbidity and mortality associated with childbirth and has negative effects on infants. Using a hormone-withdrawal challenge to precipitate mood symptoms will improve our ability to identify the biological mechanisms underlying both the triggering of and susceptibility to depressive disorders in women; and will permit the prediction of those at risk for PPD and other reproductive-related mood disorders.
Primary Outcome
The primary outcome measure was functional magnetic resonance imaging (fMRI) data collected during a Monetary Incentive Delay (MID) Task. The BOLD response was examined within the nucleus accumbens, a brain region that responds to monetary rewards. The z statistic represents the maximum contrast between win versus non-win outcomes during the MID task in the nucleus accumbens, averaged across the participants in each group. The mean BOLD response ranged from z=1.7 to 2.3; higher z scores indicate
Interventions
- DRUG Leuprolide Acetate
- DRUG Progesterone
- DRUG Micronized estradiol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2013-08 |
| Est. Completion | 2016-10-13 |
| Phase | NA |
What the finished NCT01762943 record still lists
NCT01762943 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which Leuprolide Acetate is the first listed.
NCT01762943 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01762943 about?
NCT01762943 is a clinical study titled "Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition". Understanding the neural and biological mechanisms by which reproductive hormones influence mood is critically important for public health given that postpartum depression (PPD) is the leading cause of morbidity and mortality associated with childbirth and has negative effects on infants. Using a ho...
What is the current status of trial NCT01762943?
This trial is currently completed. It is a NA study. The enrollment target is 36 participants. The study started on 2013-08. Estimated completion is 2016-10-13.
What interventions are being tested in trial NCT01762943?
The interventions under investigation include: Leuprolide Acetate (DRUG), Progesterone (DRUG), Micronized estradiol (DRUG).
Who is sponsoring clinical trial NCT01762943?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01762943's enrollment target sits among peer trials
36 1541st of 2000 higher than 437 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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