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NCT01610011 · ClinicalTrials.gov registry record · NA
Acute Glycine Pharmacodynamic Study
A NA study, sponsored by Mclean Hospital.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT01610011 is a NA study that has completed, run by Mclean Hospital. The registered enrollment target is 21 participants.
The verdict
NCT01610011, a NA study, has completed, sponsored by Mclean Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
The purpose of this study is to use proton magnetic resonance spectroscopy (MRS) at 4 Tesla to measure brain glycine levels noninvasively at baseline and for 2 hours after a single oral dose of a concentrated glycine-containing beverage, and to compare MRS glycine measurements to glycine blood levels in samples obtained after each MRS spectrum. The investigators hypothesize that they will observe a high correlation between the magnitude increases in brain and plasma glycine levels over this time frame. The investigators also hypothesize that we will observe large intersubject variability in glycine uptake rates into brain and blood. The investigators also hypothesize that subjects with a glycine decarboxylase (GLDC) mutation (triplication) will have lower baseline plasma and brain glycine levels and will experience smaller brain and plasma glycine increases after glycine consumption than controls or family members without the GLDC mutation.
Interventions
- DIETARY_SUPPLEMENT Glycine administration
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2010-07 |
| Est. Completion | 2013-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01610011
The ClinicalTrials.gov registry entry for NCT01610011 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mclean Hospital, which has 140 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Glycine administration is the first listed.
NCT01610011 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01610011 about?
NCT01610011 is a clinical study titled "Acute Glycine Pharmacodynamic Study". The purpose of this study is to use proton magnetic resonance spectroscopy (MRS) at 4 Tesla to measure brain glycine levels noninvasively at baseline and for 2 hours after a single oral dose of a concentrated glycine-containing beverage, and to compare MRS glycine measurements to glycine blood level...
What is the current status of trial NCT01610011?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2010-07. Estimated completion is 2013-12.
What interventions are being tested in trial NCT01610011?
The interventions under investigation include: Glycine administration (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01610011?
This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.
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