Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01158820 · ClinicalTrials.gov registry record · Phase 4
Alternative Sedation During Bronchoscopy
A Phase 4 study of Sedation, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT01158820: Completed Phase 4 study of Sedation, sponsored by University of Pennsylvania.
NCT01158820 is a Phase 4 study of Sedation that has completed, run by University of Pennsylvania. The registered enrollment target is 50 participants, below the 100,182-participant average among 12 other Sedation trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01158820, a Phase 4 study of Sedation, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.
Primary Outcome
An initial baseline minute ventilation estimate was obtained via calibrated respiratory impedance plethysmography bands. Subsequent minute ventilation was normalized to this value. Values exceeding 100% were excluded from analysis, as these typically reflected a period of hyperpnea subsequent to relief of airway obstruction by chin lift or jaw thrust.
Conditions Studied
Interventions
- DRUG Dexmedetomidine load
- DRUG Ketamine load
- DRUG Midazolam load
- DRUG Fentanyl load
- DRUG Dexmedetomidine maintenance
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2010-06 |
| Est. Completion | 2012-05 |
| Phase | Phase 4 |
What the finished NCT01158820 record still lists
NCT01158820 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 100,182-participant average among 12 other Sedation trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Sedation appearing as the primary indexed condition, and to 5 interventions - of which Dexmedetomidine load is the first listed.
NCT01158820 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01158820 about?
NCT01158820 is a clinical study titled "Alternative Sedation During Bronchoscopy". This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.
What is the current status of trial NCT01158820?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2010-06. Estimated completion is 2012-05.
What conditions does trial NCT01158820 study?
This clinical trial studies the following conditions: Sedation.
What interventions are being tested in trial NCT01158820?
The interventions under investigation include: Dexmedetomidine load (DRUG), Ketamine load (DRUG), Midazolam load (DRUG), Fentanyl load (DRUG), Dexmedetomidine maintenance (DRUG).
Who is sponsoring clinical trial NCT01158820?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01158820 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sedation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01158820's enrollment target sits among peer trials
50 10th of 12 higher than 3 of 12 other Sedation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sedation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Oral vs IV Sedation for Cataract Surgery in Older Adults
RECRUITING · Phase 4
-
Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation
COMPLETED · Phase 4
-
Neurosteer Bedside Monitoring System
RECRUITING · NA
-
Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration
RECRUITING · Phase 3
-
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
RECRUITING
-
A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol
ACTIVE NOT RECRUITING · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00200889 · 50 participants · Early Phase 1
Mapping Auricular Vagus Nerve Circuitry
- NCT00409435 · 50 participants · Phase 2
A Study of Pyridostigmine in Postural Tachycardia Syndrome
- NCT01202305 · 50 participants
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
- NCT01225913 · 50 participants · Phase 4
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia