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NCT00901459 · ClinicalTrials.gov registry record · Phase 2
A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers
A Phase 2 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 2
- Development phase
- 21
- Enrollment target
NCT00901459: Completed Phase 2 study, sponsored by Duke University.
NCT00901459 is a Phase 2 study that has completed, run by Duke University. The registered enrollment target is 21 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (84% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00901459, a Phase 2 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 21 participants
- Enrollment target
Study Summary
The purpose of this study is to investigate the use of repetitive transcranial magnetic stimulation (rTMS) to block craving for cigarettes in smokers. rTMS is an investigational procedure, where a device called a "stimulator" provides electricity to a device that creates a magnetic field. This device is placed against the scalp in the front of the head so that the magnetic field is focused on an area of the brain that is thought to be involved in craving for cigarettes. rTMS is an investigational procedure so therefore being tested in research studies and is not approved by the U.S. Food and Drug Administration (FDA). Changes in magnetic fields during rTMS administration change electrical currents which may affect brain activity and function.
Primary Outcome
Cigarette craving was assessed orally during each rTMS Session, before and after each stimulus presentation and cigarette smoking with a brief version of the Shiffman-Jarvik questionnaire (14), which contained items assessing cigarette craving using the following subscale: CRAVING ("urges to smoke," "miss a cigarette," and "crave cigarettes"), MOOD ("calm," "tense," and "irritable"), AROUSAL ("wide awake," "able to concentrate"), and HUNGER ("feel hungry"). The scale for the Shiffman-Jarvik ques
Interventions
- DEVICE Active rTMS Condition
- DEVICE rTMS Location Control Condition
- DEVICE rTMS Frequency Control Condition
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2009-05 |
| Est. Completion | 2010-08 |
| Phase | Phase 2 |
What the finished NCT00901459 record still lists
NCT00901459 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (84% lower).
The record links to 0 conditions, and to 3 interventions - of which Active rTMS Condition is the first listed.
NCT00901459 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00901459 about?
NCT00901459 is a clinical study titled "A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers". The purpose of this study is to investigate the use of repetitive transcranial magnetic stimulation (rTMS) to block craving for cigarettes in smokers. rTMS is an investigational procedure, where a device called a "stimulator" provides electricity to a device that creates a magnetic field. This devic...
What is the current status of trial NCT00901459?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 21 participants. The study started on 2009-05. Estimated completion is 2010-08.
What interventions are being tested in trial NCT00901459?
The interventions under investigation include: Active rTMS Condition (DEVICE), rTMS Location Control Condition (DEVICE), rTMS Frequency Control Condition (DEVICE).
Who is sponsoring clinical trial NCT00901459?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00901459's enrollment target sits among peer trials
21 1794th of 2000 higher than 196 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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