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ACTIVE NOT RECRUITING Phase 2

Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases

NCT00716066 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a stem cell transplant works in treating patients with autoimmune neurologic disease that did not respond to previous therapy. In autoimmune neurological diseases, the patient's own immune system 'attacks' the nervous system which might include the brain/spinal cord and/or the peripheral nerves. Giving high-dose chemotherapy, including carmustine, etoposide, cytarabine, melphalan, and antithymocyte globulin, before a stem cell transplant weakens the immune system and may help stop the immune system from 'attacking' a patient's nervous system. When the patient's own (autologous) stem cells are infused into the patient they help the bone marrow make red blood cells, white blood cells, and platelets so the blood counts can improve.

Interventions

  • DRUG Etoposide
  • BIOLOGICAL Anti-Thymocyte Globulin
  • DRUG Cytarabine
  • DRUG Carmustine
  • PROCEDURE Autologous Hematopoietic Stem Cell Transplantation

Study Locations (3)

Washington

  • Fred Hutch/University of Washington Cancer Consortium — Seattle
  • Swedish Medical Center-First Hill — Seattle

Colorado

  • Colorado Blood Cancer Institute — Denver

Trial Details

FieldValue
Enrollment Target 53 participants
Start Date 2008-06
Est. Completion 2030-01-31
Phase Phase 2

Sponsor

Fred Hutchinson Cancer Center

319 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00716066

The ClinicalTrials.gov registry entry for NCT00716066 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 53 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Fred Hutchinson Cancer Center, which has 319 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Autoimmune Disease appearing as the primary indexed condition, and to 5 interventions — of which Etoposide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00716066 reports 3 study locations spanning 2 distinct geographic areas — top geographies include Washington, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00716066 about?

NCT00716066 is a clinical study titled "Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases". This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a stem cell transplant works in treating patients with autoimmune neurologic disease that did not respond to previous therapy. In autoimmune neurologi...

What is the current status of trial NCT00716066?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 53 participants. The study started on 2008-06. Estimated completion is 2030-01-31.

What conditions does trial NCT00716066 study?

This clinical trial studies the following conditions: Autoimmune Disease, Neurologic Autoimmune Disease, Stiff Person Syndrome, Autologous Transplant Autoimmune, Multiple Sclerosis Transplant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00716066?

The interventions under investigation include: Etoposide (DRUG), Anti-Thymocyte Globulin (BIOLOGICAL), Cytarabine (DRUG), Carmustine (DRUG), Autologous Hematopoietic Stem Cell Transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00716066?

This trial is sponsored by Fred Hutchinson Cancer Center, which has 319 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00716066 being conducted?

This trial has 3 study locations across Colorado, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial