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NCT00667875 · ClinicalTrials.gov registry record · Phase 2
An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence
A Phase 2 study of Alcohol Dependence, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 65
- Enrollment target
- 1
- Study location
NCT00667875: Completed Phase 2 study of Alcohol Dependence, sponsored by Medical University of South Carolina.
NCT00667875 is a Phase 2 study of Alcohol Dependence that has completed, run by Medical University of South Carolina. The registered enrollment target is 65 participants, below the 312-participant average among 43 other Alcohol Dependence trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00667875, a Phase 2 study of Alcohol Dependence, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 65 participants
- Enrollment target
- 1
- Study location
Study Summary
The principal aim of this exploratory study is to examine whether the addition of aripiprazole to naltrexone will enhance efficacy over naltrexone alone in a 16-week randomized, placebo-controlled clinical trial, in which all subjects will be provided medical management as delivered in the COMBINE Study (Anton et al, 2006). To test whether medication treatment will reduce drinking compared to placebo treatment alone in the context of medical management and whether naltrexone plus aripiprazole will reduce drinking compared to naltrexone treatment alone in the context of medical management.
Primary Outcome
Standard drinks per drinking day
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Naltrexone
- DRUG Naltrexone + Aripiprazole
Study Locations (1)
South Carolina
- Medical University of South Carolina, Center for Drug and Alcohol Programs - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2008-04 |
| Est. Completion | 2011-05 |
| Phase | Phase 2 |
What the finished NCT00667875 record still lists
NCT00667875 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 65 participants, a relatively small participant target, below the 312-participant average among 43 other Alcohol Dependence trials with a reported enrollment target (79% lower).
The record links to 1 condition, with Alcohol Dependence appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT00667875 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT00667875 about?
NCT00667875 is a clinical study titled "An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence". The principal aim of this exploratory study is to examine whether the addition of aripiprazole to naltrexone will enhance efficacy over naltrexone alone in a 16-week randomized, placebo-controlled clinical trial, in which all subjects will be provided medical management as delivered in the COMBINE S...
What is the current status of trial NCT00667875?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 65 participants. The study started on 2008-04. Estimated completion is 2011-05.
What conditions does trial NCT00667875 study?
This clinical trial studies the following conditions: Alcohol Dependence.
What interventions are being tested in trial NCT00667875?
The interventions under investigation include: Placebo (DRUG), Naltrexone (DRUG), Naltrexone + Aripiprazole (DRUG).
Who is sponsoring clinical trial NCT00667875?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00667875 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00667875's enrollment target sits among peer trials
65 31st of 43 higher than 13 of 43 other Alcohol Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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