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NCT00602641 · ClinicalTrials.gov registry record · Phase 3
Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma
A Phase 3 study of Multiple Myeloma, sponsored by National Cancer Institute (NCI).
- Active
- Registry status
- Phase 3
- Development phase
- 306
- Enrollment target
- 20
- Study locations
NCT00602641: Active Phase 3 study of Multiple Myeloma, sponsored by National Cancer Institute (NCI).
NCT00602641 is a Phase 3 study of Multiple Myeloma that is active but no longer recruiting, run by National Cancer Institute (NCI). The registered enrollment target is 306 participants, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (44% lower). The trial reports 20 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00602641, a Phase 3 study of Multiple Myeloma, is active but no longer recruiting, sponsored by National Cancer Institute (NCI).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 306 participants
- Enrollment target
- 20
- Study locations
Study Summary
This randomized phase III trial studies melphalan and prednisone with thalidomide to see how well it works compared to melphalan and prednisone together with lenalidomide in treating patients with newly diagnosed multiple myeloma. Drugs used in chemotherapy, such as melphalan and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Thalidomide and lenalidomide may stop the growth of multiple myeloma by blocking blood flow to the cancer. It is not yet known whether melphalan and prednisone are more effective when given together with thalidomide or lenalidomide in treating multiple myeloma.
Primary Outcome
PFS is defined as the time from randomization to the earlier of progression or death of any cause.
Conditions Studied
Interventions
- DRUG Melphalan
- OTHER Quality-of-Life Assessment
- OTHER Laboratory Biomarker Analysis
- DRUG Lenalidomide
- DRUG Prednisone
Study Locations (20)
Colorado
- The Medical Center of Aurora - Aurora
- Boulder Community Foothills Hospital - Boulder
- Penrose-Saint Francis Healthcare - Colorado Springs
- AdventHealth Porter - Denver
- Presbyterian - Saint Lukes Medical Center - Health One - Denver
- Saint Joseph Hospital - Cancer Centers of Colorado - Denver
- Rose Medical Center - Denver
- Western States Cancer Research NCORP - Denver
- Swedish Medical Center - Englewood
California
- UC San Diego Moores Cancer Center - La Jolla
- Fremont - Rideout Cancer Center - Marysville
- Memorial Medical Center - Modesto
- University of California Davis Comprehensive Cancer Center - Sacramento
- UC San Diego Medical Center - Hillcrest - San Diego
- Kaiser Permanente-San Diego Mission - San Diego
- San Diego VA Medical Center - San Diego
- Gene Upshaw Memorial Tahoe Forest Cancer Center - Truckee
Alabama
- Providence Hospital - Mobile
Arizona
- Mayo Clinic in Arizona - Scottsdale
Arkansas
- Sparks Regional Medical Center - Fort Smith
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 306 participants |
| Start Date | 2008-02-29 |
| Est. Completion | 2026-02-22 |
| Phase | Phase 3 |
What the registry record for NCT00602641 still lists
NCT00602641 is an interventional study that assigns participants to a tested intervention. The registered 306 participants enrollment target is mid-sized for trials with a published cap, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (44% lower).
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions - of which Melphalan is the first listed.
NCT00602641 names 20 study sites across 5 states, led by Colorado, California, Alabama.
Frequently Asked Questions
What is clinical trial NCT00602641 about?
NCT00602641 is a clinical study titled "Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma". This randomized phase III trial studies melphalan and prednisone with thalidomide to see how well it works compared to melphalan and prednisone together with lenalidomide in treating patients with newly diagnosed multiple myeloma. Drugs used in chemotherapy, such as melphalan and prednisone, work in...
What is the current status of trial NCT00602641?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 306 participants. The study started on 2008-02-29. Estimated completion is 2026-02-22.
What conditions does trial NCT00602641 study?
This clinical trial studies the following conditions: Multiple Myeloma.
What interventions are being tested in trial NCT00602641?
The interventions under investigation include: Melphalan (DRUG), Quality-of-Life Assessment (OTHER), Laboratory Biomarker Analysis (OTHER), Lenalidomide (DRUG), Prednisone (DRUG).
Who is sponsoring clinical trial NCT00602641?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00602641 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00602641's enrollment target sits among peer trials
306 73rd of 438 higher than 366 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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