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Study Looking at the Recovery of New Onset Cardiomyopathy
NCT00575211 · View on ClinicalTrials.gov ↗
Study Summary
This is a multi-center, prospective evaluation of left ventricular recovery on conventional therapy in patients with the recent onset of dilated cardiomyopathy. In some subjects with this disorder, the heart will recover significantly over the first year, while others will be left with a chronically weak heart. The proteins that help the heart recover are encoded by genes, which can differ markedly between individuals. The goal of the current study is to determine whether variation in these genes involved affect the probability that the heart will recover. We will also look at which genes are involved in inflammation and which ones are "turned on" (producing proteins) in circulating white blood cells.{These statements will only be added if the site has chosen to participate in RNA analysis}. In addition, this study will look at how levels of proteins in the blood, proteins called "cytokines' which control inflammation and proteins called "neurohormones" which are released when the heart weakens, affect the likelihood of recovery. Enrollment will take place at 15 centers. The goal is to enroll approximately 500 adult subjects (age 18 years or older, both men and women) over the course of approximately 48 months.
Conditions Studied
Study Locations (16)
Pennsylvania
- Milton S. Hershey Medical Center — Hershey
- Thomas Jefferson University — Philadelphia
- University of Pittsburgh Medical Center — Pittsburgh
Texas
- University of Texas Southwestern Medical Center — Dalls
- The Methodist Hospital — Houston
California
- University of California - Irvine — Orange
Florida
- University of Florida — Gainesville
Maryland
- Johns Hopkins University — Baltimore
Massachusetts
- Massachusetts General Hospital — Boston
Minnesota
- Mayo Clinic — Rochester
New Jersey
- Newark Beth Israel Medical Center — Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 373 participants |
| Start Date | 2004-01 |
| Est. Completion | 2011-03 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00575211
The ClinicalTrials.gov registry entry for NCT00575211 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 373 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,082 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Cardiomyopathy appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00575211 reports 16 study locations spanning 13 distinct geographic areas — top geographies include Pennsylvania, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00575211 about?
NCT00575211 is a clinical study titled "Study Looking at the Recovery of New Onset Cardiomyopathy". This is a multi-center, prospective evaluation of left ventricular recovery on conventional therapy in patients with the recent onset of dilated cardiomyopathy. In some subjects with this disorder, the heart will recover significantly over the first year, while others will be left with a chronically...
What is the current status of trial NCT00575211?
This trial is currently completed. The enrollment target is 373 participants. The study started on 2004-01. Estimated completion is 2011-03.
What conditions does trial NCT00575211 study?
This clinical trial studies the following conditions: Cardiomyopathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT00575211?
This trial is sponsored by University of Pittsburgh, which has 1,082 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00575211 being conducted?
This trial has 16 study locations across California, Florida, Maryland, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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