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NCT00075296 · ClinicalTrials.gov registry record
FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression
A clinical trial of Major Depressive Disorder, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT00075296: Completed study of Major Depressive Disorder, sponsored by National Institute of Mental Health (NIMH).
NCT00075296 is a study of Major Depressive Disorder that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 100 participants, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (73% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00075296, a study of Major Depressive Disorder, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine how the brains of depressed people function during learning and respond to feedback. Participants perform a "probabilistic reversal learning task" to determine whether depressed people perform worse on a task than non-depressed people when they sometimes receive misleading negative feedback. Right-handed healthy volunteers, people with major depression who are currently depressed or have previously been depressed and people with bipolar depression between 18 and 50 years of age may be eligible for this study. Candidates are screened with a medical and psychiatric history, physical examination, electrocardiogram, blood and urine tests. They are also interviewed to evaluate mood, sleep, energy, work and school performance, and social relationships, and asked to answer questions to investigate whether any history of paranoia, panic attacks, obsession, compulsions, suicidal thoughts, eating disturbances, and alcohol or drug abuse is present. They complete rating scales for depression, anxiety, and negative thinking; history of alcohol and tobacco use; physical movement; socioeconomic status; overall level of functioning; and depression type. Finally, they undergo a battery of neuropsychological tests to assess general intelligence, handedness, and specific cognitive abilities, including memory and concentration. Participants perform the probabilistic reversal learning task either in a testing room seated in front of a computer or lying down while undergoing functional magnetic resonance imaging (FMRI). FMRI is a diagnostic test that uses a strong magnet and radio waves to obtain pictures of brain structure and function. For the scan, the subject lies on a narrow bed with a plastic-encased metal coil close to the head. The bed slides into the scanner - a small tunnel about 6 feet long. All subjects, whether in the testing room or in the MRI scanner, undergo the learning task as follows: Two patterns are presented on a computer screen. One patte
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2004-01-05 |
| Est. Completion | 2008-04-21 |
What the finished NCT00075296 record still lists
NCT00075296 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (73% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 0 interventions.
NCT00075296 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00075296 about?
NCT00075296 is a clinical study titled "FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression". This study will examine how the brains of depressed people function during learning and respond to feedback. Participants perform a "probabilistic reversal learning task" to determine whether depressed people perform worse on a task than non-depressed people when they sometimes receive misleading ne...
What is the current status of trial NCT00075296?
This trial is currently completed. The enrollment target is 100 participants. The study started on 2004-01-05. Estimated completion is 2008-04-21.
What conditions does trial NCT00075296 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
Who is sponsoring clinical trial NCT00075296?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00075296 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00075296's enrollment target sits among peer trials
100 132nd of 282 higher than 145 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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