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NCT00055003 · ClinicalTrials.gov registry record
Effect of Hydrocortisone on the Brain
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 80
- Enrollment target
NCT00055003 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 80 participants.
The verdict
NCT00055003 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 80 participants
- Enrollment target
Study Summary
The purpose of this study is to use brain imaging technology to examine the effect of the hormone hydrocortisone on the brain's response to various facial expressions. Glucocorticoids can influence emotional behavior and cognition; when given long-term, the hormones may lead to mania or depression. One way glucocorticoids may influence emotional behavior is by affecting the activity of certain parts of the brain that participate in emotional processing. Brain imaging studies indicate that the amygdala, ventral medial prefrontal, and other prefrontal cortical areas of the brain are activated during tasks that require processing of emotional stimuli. These brain structures contain dense concentrations of glucocorticoid receptors. This study will use functional magnetic resonance imaging (fMRI) to study the brain activity of participants as they view faces that express different emotions. Participants will perform this task under a dose of either the glucocorticoid hydrocortisone or placebo (an inactive solution). Participants in this study will be screened with a medical history, physical examination, blood tests, and an interview about their mood, degree of nervousness, and behavior. On Visit 1, participants will undergo screening and neuropsychological testing. For 3 days prior to Visit 2, participants will collect their saliva. During Visit 2, participants will undergo MRI scans of the brain after infusion with either a high or low dose of hydrocortisone or placebo. Participants will also undergo functional MRI (fMRI). Blood samples will be collected every 15 minutes during the scan. Following the MRI, participants will take attention and memory tests. ...
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2003-02-13 |
| Est. Completion | 2010-11-18 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00055003
The ClinicalTrials.gov registry entry for NCT00055003 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Mental Health (NIMH), which has 343 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00055003 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00055003 about?
NCT00055003 is a clinical study titled "Effect of Hydrocortisone on the Brain". The purpose of this study is to use brain imaging technology to examine the effect of the hormone hydrocortisone on the brain's response to various facial expressions. Glucocorticoids can influence emotional behavior and cognition; when given long-term, the hormones may lead to mania or depression....
What is the current status of trial NCT00055003?
This trial is currently completed. The enrollment target is 80 participants. The study started on 2003-02-13. Estimated completion is 2010-11-18.
Who is sponsoring clinical trial NCT00055003?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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