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NCT01189786 · ClinicalTrials.gov registry record · NA
Ex Vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells Via CD34-Selection
A NA study of Stem Cell Transplant and Allogeneic, sponsored by Baylor College of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 241
- Enrollment target
- 2
- Study locations
NCT01189786 is a NA study of Stem Cell Transplant and Allogeneic that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 241 participants, above the 170-participant average among 9 other Stem Cell Transplant trials with a reported enrollment target (42% higher). The trial reports 2 study locations across 1 state.
The verdict
NCT01189786, a NA study of Stem Cell Transplant and Allogeneic, is actively recruiting participants, sponsored by Baylor College of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 241 participants
- Enrollment target
- 2
- Study locations
Study Summary
Participants are being asked to take part in this study because treatment of his or her disease requires a stem cell transplant. Stem cells or "mother" cells are the source of normal blood cells and lead to recovery of blood counts after bone marrow transplantation. Unfortunately, there is not a perfectly matched stem cell donor (like a sister or brother) for the participant and his or her disease does not permit enough time to identify another donor (like someone from a registry list that is not his or her relative) or another suitable donor has not been identified. However, a close relative of the patient has been identified whose stem cells are not a perfect match, but can be used. Alternatively, the patient may have already received a stem cell transplant but have evidence of mixed chimerism, which means some of the patient's own bone marrow cells are present, rather than all of the donor's cells. This may lead to an increased risk of the disease coming back. Or, the patient may have all donor cells but his or her bone marrow is not working very well, which may lead to frequent blood or platelet (cells that help in clotting blood) transfusions or infection. Regardless of the reason, it may be necessary to isolate stem cells from a haploidentical (half-match) donor in order to provide bone marrow function. Because the stem cells from the donor are only half-matched to the participant, the risk of graft-versus-host disease (GvHD) is very high. GvHD is a complication after transplant caused by donor T cells (graft) that attack the transplant recipient, and this complication can cause death after transplant. Thus, it is important that the donor's blood cells are treated to minimize cells that are most likely to attack the host's tissues. This is done by using a special device to capture the CD34+ stem cells from the donor's stem cell product prior to giving the cells to the host. This method minimizes the donor T cells, which are responsible for causing GvHD. Pur
Conditions Studied
Interventions
- DEVICE CliniMACS CD34 Reagent system
Study Locations (2)
Texas
- Houston Methodist Hospital - Houston
- Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 241 participants |
| Start Date | 2010-10 |
| Est. Completion | 2027-11 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01189786
The ClinicalTrials.gov registry entry for NCT01189786 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 241 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 170-participant average among 9 other Stem Cell Transplant trials with a reported enrollment target (42% higher). The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Stem Cell Transplant appearing as the primary indexed condition, and to 1 intervention - of which CliniMACS CD34 Reagent system is the first listed.
NCT01189786 reports 2 study locations spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT01189786 about?
NCT01189786 is a clinical study titled "Ex Vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells Via CD34-Selection". Participants are being asked to take part in this study because treatment of his or her disease requires a stem cell transplant. Stem cells or "mother" cells are the source of normal blood cells and lead to recovery of blood counts after bone marrow transplantation. Unfortunately, there is not a per...
What is the current status of trial NCT01189786?
This trial is currently recruiting. It is a NA study. The enrollment target is 241 participants. The study started on 2010-10. Estimated completion is 2027-11.
What conditions does trial NCT01189786 study?
This clinical trial studies the following conditions: Stem Cell Transplant, Allogeneic.
What interventions are being tested in trial NCT01189786?
The interventions under investigation include: CliniMACS CD34 Reagent system (DEVICE).
Who is sponsoring clinical trial NCT01189786?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01189786 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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