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NCT00018096 · ClinicalTrials.gov registry record · NA
The Genetics of Environmental Asthma
A NA study of Asthma, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Completed
- Registry status
- NA
- Development phase
- 176
- Enrollment target
- 1
- Study location
NCT00018096: Completed NA study of Asthma, sponsored by National Institute of Environmental Health Sciences (NIEHS).
NCT00018096 is a NA study of Asthma that has completed, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 176 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00018096, a NA study of Asthma, has completed, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- COMPLETED
- Registry status
- NA
- Development phase
- 176 participants
- Enrollment target
- 1
- Study location
Study Summary
In this project, we hypothesize that polymorphisms of genes expressed by the airway epithelia in asthmatics following specific airway challenges predispose individuals to the development of asthma. To test this hypothesis, we identify the genes that are differentially expressed by airway epithelial cells following challenge with stimuli that induce acquired (house dust mite) or innate (LPS) immune responses, and then determine whether polymorphisms in these genes are associated with the development of asthma in a separate, well characterized, familial cohort of asthmatics. This is a powerful approach that is designed to identify novel genes that are associated with both asthma pathogenesis (differentially expressed in the exposure-response study) and asthma susceptibility (genetically associated with asthma in a linkage/association study).
Conditions Studied
Interventions
- BIOLOGICAL LPS endotoxin, saline, HDM
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 176 participants |
| Start Date | 2001-06 |
| Est. Completion | 2007-12 |
| Phase | NA |
What the finished NCT00018096 record still lists
NCT00018096 is an interventional study that assigns participants to a tested intervention. The registered 176 participants enrollment target is mid-sized for trials with a published cap, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (89% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 1 intervention - of which LPS endotoxin, saline, HDM is the first listed.
NCT00018096 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT00018096 about?
NCT00018096 is a clinical study titled "The Genetics of Environmental Asthma". In this project, we hypothesize that polymorphisms of genes expressed by the airway epithelia in asthmatics following specific airway challenges predispose individuals to the development of asthma. To test this hypothesis, we identify the genes that are differentially expressed by airway epithelial ...
What is the current status of trial NCT00018096?
This trial is currently completed. It is a NA study. The enrollment target is 176 participants. The study started on 2001-06. Estimated completion is 2007-12.
What conditions does trial NCT00018096 study?
This clinical trial studies the following conditions: Asthma.
What interventions are being tested in trial NCT00018096?
The interventions under investigation include: LPS endotoxin, saline, HDM (BIOLOGICAL).
Who is sponsoring clinical trial NCT00018096?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00018096 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00018096's enrollment target sits among peer trials
176 174th of 374 higher than 201 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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