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NCT06788093 · ClinicalTrials.gov registry record · NA

Reducing Overuse of Antibiotics With Decision Support

A NA study of Asthma and Pneumonia, sponsored by Vanderbilt University Medical Center.

Recruiting
Registry status
NA
Development phase
2,800
Enrollment target
3
Study locations

NCT06788093: Recruiting NA study of Asthma and Pneumonia, sponsored by Vanderbilt University Medical Center.

NCT06788093 is a NA study of Asthma and Pneumonia that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 2,800 participants, above the 1,556-participant average among 374 other Asthma trials with a reported enrollment target (80% higher). The trial reports 3 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06788093, a NA study of Asthma and Pneumonia, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.

RECRUITING
Registry status
NA
Development phase
2,800 participants
Enrollment target
3
Study locations

Study Summary

Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research. LRTIs (pneumonia, bronchiolitis, and infection-related exacerbations of asthma) account for nearly one-third of all emergency department (ED) visits and 40% of all infection-related hospitalizations in US children. LRTIs also account for more antibiotic use in children's hospitals than any other condition, despite most LRTIs being viral in nature. Inappropriate antibiotics are associated with substantial adverse effects. Accordingly, national guidelines strongly discourage routine antibiotic use for bronchiolitis and acute asthma and argue for significantly reducing antibiotic exposure (initiation, spectrum, and duration) in pneumonia. To address the problem of inappropriate antibiotic use, hospital-based antimicrobial stewardship programs (ASPs) are now common nationwide, and these programs have demonstrated effectiveness in some hospital settings. Unfortunately, traditional ASP approaches do not translate well to the fast-paced and unpredictable ED environment, and hospital-based ASP resources are finite and not always immediately available. Clinical decision support (CDS) embedded within the electronic health record (EHR) is a strategy that could address the ED antibiotic stewardship gap. Informed by a deep understanding of the key facilitators and barriers to using CDS to support appropriate antibiotic use in ED and hospital settings, the investigators have developed two stewardship-focused CDS interventions for pediatric LRTI. The overarching goal of this research is to rigorously evaluate the implementation and effectiveness of these CDS tools, alone and in combination, against usual care only in a pragmatic randomized clinical trial at 3 U.S. children's hospitals.

Primary Outcome

The Antibiotic Spectrum Index (ASI) is a numerical metric which quantifies the relative breadth of antimicrobial activity of a given antibiotic medication. Tracking the 10-day trajectory of ASI will capture changes in antibiotic use resulting from changes in antibiotic initiation, spectrum of antibiotic activity, and duration of antibiotic use.

Conditions Studied

Asthma Pneumonia Lower Respiratory Tract Infection Bronchiolitis, Viral

Interventions

  • BEHAVIORAL ED Clinical Decision Support (CDS-ED)
  • BEHAVIORAL Transitions Clinical Decision Support (CDS-Tr)

Study Locations (3)

California

  • Benioff Children's Hospital - Oakland - Oakland
  • Benioff Children's Hospital - San Francisco - San Francisco

Tennessee

  • Monroe Carell Jr Children's Hospital at Vanderbilt - Nashville

Trial Details

FieldValue
Enrollment Target 2,800 participants
Start Date 2024-11-12
Est. Completion 2027-04
Phase NA
Vanderbilt University Medical Center

677 total trials

What NCT06788093 shows while recruiting

NCT06788093 is an interventional study that assigns participants to a tested intervention. Its 2,800 participants enrollment target places it among the larger protocols in the corpus, above the 1,556-participant average among 374 other Asthma trials with a reported enrollment target (80% higher).

The record links to 4 conditions, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which ED Clinical Decision Support (CDS-ED) is the first listed.

NCT06788093 reports a single indexed study location in California, Tennessee.

Frequently Asked Questions

What is clinical trial NCT06788093 about?

NCT06788093 is a clinical study titled "Reducing Overuse of Antibiotics With Decision Support". Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research. LRTIs (pneumonia, bronchiolitis, and infection-related exacerbations of asthma) account for nearly one-third of all emergency department (ED) visits and 40% of all i...

What is the current status of trial NCT06788093?

This trial is currently recruiting. It is a NA study. The enrollment target is 2,800 participants. The study started on 2024-11-12. Estimated completion is 2027-04.

What conditions does trial NCT06788093 study?

This clinical trial studies the following conditions: Asthma, Pneumonia, Lower Respiratory Tract Infection, Bronchiolitis, Viral.

What interventions are being tested in trial NCT06788093?

The interventions under investigation include: ED Clinical Decision Support (CDS-ED) (BEHAVIORAL), Transitions Clinical Decision Support (CDS-Tr) (BEHAVIORAL).

Who is sponsoring clinical trial NCT06788093?

This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06788093 being conducted?

This trial has 3 study locations across California, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Asthma

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06788093's enrollment target sits among peer trials

2,800 19th of 374 higher than 356 of 374 other Asthma trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT06788093

Source: ClinicalTrials.gov NCT06788093, the US trial registry maintained by the National Library of Medicine. NCT06788093 (large enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.