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NCT00001543 · ClinicalTrials.gov registry record
Dynamics of Leptin and Endocrine Function
A clinical trial of Healthy and Involutional Depression, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 230
- Enrollment target
- 1
- Study location
NCT00001543: Completed study of Healthy and Involutional Depression, sponsored by National Institute of Mental Health (NIMH).
NCT00001543 is a study of Healthy and Involutional Depression that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 230 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001543, a study of Healthy and Involutional Depression, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 230 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a study investigating the hormones and substances important to the stress response. The hormone that is most directly responsible for stress response is called corticotropin-releasing hormone (CRH). CRH is produced in the hypothalamus of the brain and causes the pituitary gland to produce another hormone called ACTH. The hormone ACTH then acts on the adrenal glands causing them to produce the hormone cortisol. Unfortunately, CRH levels are unable to be measured in simple blood samples. However, substances like cortisol and leptin can provide information as to the activity of the hypothalamus. The hormone leptin is associated with the regulation of body weight and the normal maintenance of bodily functions (homeostasis). It is found in fat cell (adipocyes) and communicates the nutritional status of the body to the brain (central nervous system). Research using animals has shown that defects in the communication between leptin and the brain causes obesity (the state of being overweight). It has also been noted that obese humans tend to have high levels of leptin. By studying patients with abnormal genes responsible for leptin production, researchers have found that a least one leptin gene must be intact for the normal secretion of hormones to proceed. These results show that the hormone leptin is produced outside of the brain in fat cells and acts directly on the function of the hypothalamus within the brain. Researchers believe that leptin plays a key role in the normal release of hormones from the HPA axis. Researchers intend on continuing to study the role of leptin in fat distribution, and the activity of the HPA axis in normal volunteers. In addition, this study will focus on the role of leptin in depression, because depression is characterized by changes in food intake, body weight, and neuroendocrine function. Data gathered from this study will provide a better understanding of the causes and medical consequences of major depression.
Conditions Studied
Study Locations (1)
Maryland
- National Institute of Mental Health (NIMH) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 230 participants |
| Start Date | 1996-03 |
| Est. Completion | 2002-06 |
What the finished NCT00001543 record still lists
NCT00001543 is an observational study that tracks outcomes without assigning an intervention. The registered 230 participants enrollment target is mid-sized for trials with a published cap, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (64% lower).
The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 0 interventions.
NCT00001543 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00001543 about?
NCT00001543 is a clinical study titled "Dynamics of Leptin and Endocrine Function". This is a study investigating the hormones and substances important to the stress response. The hormone that is most directly responsible for stress response is called corticotropin-releasing hormone (CRH). CRH is produced in the hypothalamus of the brain and causes the pituitary gland to produce an...
What is the current status of trial NCT00001543?
This trial is currently completed. The enrollment target is 230 participants. The study started on 1996-03. Estimated completion is 2002-06.
What conditions does trial NCT00001543 study?
This clinical trial studies the following conditions: Healthy, Involutional Depression.
Who is sponsoring clinical trial NCT00001543?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00001543 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00001543's enrollment target sits among peer trials
230 108th of 1090 higher than 983 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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