Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Smallpox: early-phase trial registry
A small indexed set (8 trials) with no open enrollment listed right now.
Corpus placement: #2,176 of 28,707 conditions by registered trial count.
8 US clinical trials · none currently recruiting · #2,176 of 28,707 conditions by registered trial count
Smallpox: 8 US clinical trials tracked, none currently recruiting.
Smallpox is the subject of 8 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 0 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Emergent BioSolutions, running 3 of these trials.
Enrollment posture brief
Registry condition smallpox
OPEN 0 | RECR 0% | LATE 0 | EARLY 5 | RANK #2176 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Accelerated Phase Chronic Myelogenous Leukemia (0% recruiting · 12 trials)
Smallpox has no open enrollment in this registry pull (8 archived studies). Peers show how other volume-matched labels compare on open share. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smallpox on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smallpox is recruiting below its size-band peers.
0 of 8 indexed trials (0%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Smallpox research.
Emergent BioSolutions accounts for 3 of 8 trials (37.5%). 4 distinct sponsors appear on at least one study for this condition label.
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Typical Smallpox enrolment sits around 523 participants.
Median target enrolment is 523 among the 8 trials that report a genuine target (sentinel values excluded). 2 of those (25%) plan for fewer than 100 participants.
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Smallpox splits between interventional and observational designs.
5 interventional and 3 observational studies make up this index (62.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Indexed trials (enrollment closed)
8 total, page 1 of 1
Study to Assess the Safety and Immunogenicity of TPOXX® When Administered Orally for 28 Days With JYNNEOS
SIGA Technologies
NCT04957485
Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
Emergent BioSolutions
NCT00927719
Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)
Emergent BioSolutions
NCT00928577
Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel
Emergent BioSolutions
NCT01540929
Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00914732
MVA Post-Event: Administration Timing and Boost Study
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00437021
Dryvax Dilution-Prev Vacc Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00032708
Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection
Bavarian Nordic
NCT02038881
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Smallpox records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smallpox trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smallpox page
8 registered trials, 0 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- No Smallpox trials are currently recruiting in this registry; that can change as new trials post, or check the broader research index. Browse research indexes
- Emergent BioSolutions sponsors the most Smallpox trials on record, review their full trial history before evaluating a specific study. See Emergent BioSolutions's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smallpox condition card totals 8 registered trials; most-linked intervention MVA Smallpox Vaccine; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.