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Osteo Arthritis Knee clinical trials
Every US clinical trial registered for Osteo Arthritis Knee — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
23 US clinical trials · 10 currently recruiting
The research picture
Osteo Arthritis Knee has 23 registered US clinical trials, 10 of them open to new participants right now — about 43% of the total.
- 10
- recruiting participants now
- 43%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 3
- top sponsor: ZetrOZ
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
Ageless Biotech
NCT06485843
Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
ZetrOZ
NCT06257537
Optimizing Pain Self-Management in Total Knee Arthroplasty
University of Virginia
NCT06038240
MISHA Post-Market Clinical Study
Moximed
NCT06118892
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Healeon Medical
NCT04238143
Gait Rehabilitation to Treat FastOA
University of North Carolina, Chapel Hill
NCT05848622
The Role of Vitamin K on Knee Osteoarthritis Outcomes
Boston University
NCT06385275
Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)
Augusta University
NCT06058169
Geniculate Artery Embolization for Osteoarthritis
University of Minnesota
NCT04456569
Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
University of California, San Diego
NCT04716803
Pain & Aging: Combined Interventions for Fitness in the Community Study
University of Washington
NCT04099394
Prospective Post Approval Clinical Follow-Up Study of the Commercially Available U2 Knee™ System - "U-Propel Study"
United Orthopedic Corporation
NCT03060057
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
Lipogems International spa
NCT06121882
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
CrannMed
NCT06550024
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
Genascence Corporation
NCT05835895
Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
Tufts University
NCT05505552
Melatonin Use After Primary Total Joint Arthroplasty
NYU Langone Health
NCT04795336
Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
ZetrOZ
NCT05882812
Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee
University of Texas at Austin
NCT04805554
Microfragmented Adipose Tissue Compared to Corticosteroid Injection for the Treatment of Knee Osteoarthritis
Lipogems International spa
NCT05660772
Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
ZetrOZ
NCT04391842
Self Cranial Electrical Stimulation (CES) for Pain in Older Adults With Knee Osteoarthritis (Self CES for Knee Pain)
The University of Texas Health Science Center, Houston
NCT04016259
Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty
Duke University
NCT03395990
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 3 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteo Arthritis Knee Trial Landscape
ClinicalTrials.gov lists 23 US studies indexed under Osteo Arthritis Knee, and 10 of those are currently open to recruitment — roughly 43% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Osteo Arthritis Knee shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 7 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Osteo Arthritis Knee is led by ZetrOZ with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 23 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteo Arthritis Knee?
PlainTrial tracks 23 US clinical trials for Osteo Arthritis Knee, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteo Arthritis Knee?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.