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NCT06450925 · ClinicalTrials.gov registry record · Phase 2
Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
A Phase 2 study of Vitamin D Deficiency and Graft Vs Host Disease, sponsored by Children's Hospital Medical Center, Cincinnati.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 190
- Enrollment target
- 3
- Study locations
NCT06450925: Recruiting Phase 2 study of Vitamin D Deficiency and Graft Vs Host Disease, sponsored by Children's Hospital Medical Center, Cincinnati.
NCT06450925 is a Phase 2 study of Vitamin D Deficiency and Graft Vs Host Disease that is actively recruiting participants, run by Children's Hospital Medical Center, Cincinnati. The registered enrollment target is 190 participants, below the 272-participant average among 48 other Vitamin D Deficiency trials with a reported enrollment target (30% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06450925, a Phase 2 study of Vitamin D Deficiency and Graft Vs Host Disease, is actively recruiting participants, sponsored by Children's Hospital Medical Center, Cincinnati.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 190 participants
- Enrollment target
- 3
- Study locations
Study Summary
The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.
Primary Outcome
Incidence of moderate-severe chronic GVHD
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Vitamin A
Study Locations (3)
Florida
- Moffitt Cancer Center - Tampa
New York
- Roswell Park Comprehensive Cancer Center - Buffalo
Ohio
- The Ohio State University - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 190 participants |
| Start Date | 2025-03-25 |
| Est. Completion | 2029-08 |
| Phase | Phase 2 |
What NCT06450925 shows while recruiting
NCT06450925 is an interventional study that assigns participants to a tested intervention. The registered 190 participants enrollment target is mid-sized for trials with a published cap, below the 272-participant average among 48 other Vitamin D Deficiency trials with a reported enrollment target (30% lower).
The record links to 3 conditions, with Vitamin D Deficiency appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06450925 reports a single indexed study location in Florida, New York, Ohio.
Frequently Asked Questions
What is clinical trial NCT06450925 about?
NCT06450925 is a clinical study titled "Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.". The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.
What is the current status of trial NCT06450925?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 190 participants. The study started on 2025-03-25. Estimated completion is 2029-08.
What conditions does trial NCT06450925 study?
This clinical trial studies the following conditions: Vitamin D Deficiency, Graft Vs Host Disease, Vitamin A Deficiency.
What interventions are being tested in trial NCT06450925?
The interventions under investigation include: Placebo (OTHER), Vitamin A (DRUG).
Who is sponsoring clinical trial NCT06450925?
This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 571 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06450925 being conducted?
This trial has 3 study locations across Florida, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Vitamin D Deficiency
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06450925's enrollment target sits among peer trials
190 7th of 48 higher than 42 of 48 other Vitamin D Deficiency trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Vitamin D Deficiency trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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