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ClinicalTrials.gov 7 recruiting now official registry

Bipolar II Disorder clinical trials

7 of 14 indexed Bipolar II Disorder trials are currently recruiting.

14 US clinical trials · 7 currently recruiting

Bipolar II Disorder is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is University of Pittsburgh, running 2 of these trials.

The research picture

Bipolar II Disorder has 14 registered US clinical trials, 7 of them open to new participants right now, about 50% of the total.

7
recruiting participants now
50%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
2
top sponsor: University of Pittsburgh
Phase 27Phase 32Phase 42

Active & Recent Trials

14 total, page 1 of 1

RECRUITING Phase 3 400 participants

A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

Xenon Pharmaceuticals

NCT07172516

RECRUITING Phase 2 195 participants

A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder

AbbVie

NCT06696755

RECRUITING Phase 4 100 participants

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

Mayo Clinic

NCT07213466

RECRUITING 80 participants

Children's Bipolar Network Treatment Trial I

University of California, Los Angeles

NCT05427123

RECRUITING Phase 2 68 participants

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

Medical University of South Carolina

NCT05064319

RECRUITING Phase 2 10 participants

Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

The University of Texas Health Science Center, Houston

NCT06706232

RECRUITING NA 10 participants

Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression

Andrew Krystal

NCT07127913

ACTIVE NOT RECRUITING NA 40 participants

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

Mclean Hospital

NCT03484494

ACTIVE NOT RECRUITING Phase 2 30 participants

Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder

BioXcel Therapeutics

NCT07116694

ACTIVE NOT RECRUITING Phase 2 14 participants

Psilocybin Therapy for Depression in Bipolar II Disorder

University of California, San Francisco

NCT05065294

COMPLETED Phase 4 75 participants

The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.

Mayo Clinic

NCT03156504

COMPLETED Phase 3 60 participants

Sensoril(Ashwaganhda)for Bipolar Disorder

University of Pittsburgh

NCT00761761

COMPLETED Phase 2 38 participants

Treating Smokers With Mental Illness

University of Minnesota

NCT03822416

COMPLETED Phase 2 25 participants

Psychotherapy for Bipolar II Depression, Pilot Study, Phase II

University of Pittsburgh

NCT00411463

Phase Distribution

PhaseTrial count
Phase 2 7
Phase 3 2
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bipolar II Disorder Trial Landscape

14 indexed Bipolar II Disorder studies · 7 recruiting (50%).

Phase mix: 4 late (III/IV) vs 7 early (I/II).

Top sponsor: University of Pittsburgh (2 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bipolar II Disorder?

PlainTrial tracks 14 US clinical trials for Bipolar II Disorder, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bipolar II Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.