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ClinicalTrials.gov 4 recruiting now official registry

Anterior Cruciate Ligament Rupture clinical trials

Every US clinical trial registered for Anterior Cruciate Ligament Rupture — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

10 US clinical trials · 4 currently recruiting

The research picture

Anterior Cruciate Ligament Rupture has 10 registered US clinical trials, 4 of them open to new participants right now — about 40% of the total.

4
recruiting participants now
40%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
1
top sponsor: Andrews Research & Education Foundation

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 450 participants

Return to Play After ACL Reconstruction With Bone Marrow Aspirate, DBM, and an Internal Brace

Marshall University

NCT06294314

RECRUITING NA 135 participants

A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products

Illinois Center for Orthopaedic Research and Education

NCT06979804

RECRUITING NA 120 participants

BFRT in Adolescents After ACL Reconstruction

Children's Healthcare of Atlanta

NCT04390035

RECRUITING Phase 4 84 participants

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

The Methodist Hospital Research Institute

NCT06511232

ACTIVE NOT RECRUITING NA 250 participants

The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration

Miach Orthopaedics

NCT03348995

ACTIVE NOT RECRUITING NA 150 participants

Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial

University of Colorado, Denver

NCT04039971

ACTIVE NOT RECRUITING NA 28 participants

Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Following ACL Surgery

Sanford Health

NCT06524349

COMPLETED Phase 4 50 participants

Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction

Emory University

NCT02189317

COMPLETED NA 40 participants

Acupuncture ACL (Anterior Cruciate Ligament)

Hospital for Special Surgery, New York

NCT03711734

COMPLETED Phase 2 24 participants

Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears

Andrews Research & Education Foundation

NCT04088227

Phase Distribution

PhaseTrial count
Phase 2 1
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anterior Cruciate Ligament Rupture Trial Landscape

ClinicalTrials.gov lists 10 US studies indexed under Anterior Cruciate Ligament Rupture, and 4 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Anterior Cruciate Ligament Rupture shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Anterior Cruciate Ligament Rupture is led by Andrews Research & Education Foundation with 1 indexed trial, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 10 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anterior Cruciate Ligament Rupture?

PlainTrial tracks 10 US clinical trials for Anterior Cruciate Ligament Rupture, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anterior Cruciate Ligament Rupture?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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