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NCT07584226 · ClinicalTrials.gov registry record · Phase 1
A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors
A Phase 1 study, sponsored by Relay Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
NCT07584226: Recruiting Phase 1 study, sponsored by Relay Therapeutics.
NCT07584226 is a Phase 1 study that is actively recruiting participants, run by Relay Therapeutics. The registered enrollment target is 35 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07584226, a Phase 1 study, is actively recruiting participants, sponsored by Relay Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
Study Summary
This is a Phase 1 first-in-human, open-label multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of RLY-8161, an NRAS-selective inhibitor, in participants with advanced NRAS-mutant melanoma and other solid tumors.
Interventions
- DRUG RLY-8161
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2026-03-09 |
| Est. Completion | 2029-12-31 |
| Phase | Phase 1 |
What NCT07584226 shows while recruiting
NCT07584226 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower).
The record links to 0 conditions, and to 1 intervention - of which RLY-8161 is the first listed.
NCT07584226 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07584226 about?
NCT07584226 is a clinical study titled "A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors". This is a Phase 1 first-in-human, open-label multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of RLY-8161, an NRAS-selective inhibitor, in participants with advanced NRAS-mutant melanoma and other solid tumor...
What is the current status of trial NCT07584226?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2026-03-09. Estimated completion is 2029-12-31.
What interventions are being tested in trial NCT07584226?
The interventions under investigation include: RLY-8161 (DRUG).
Who is sponsoring clinical trial NCT07584226?
This trial is sponsored by Relay Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07584226's enrollment target sits among peer trials
35 1258th of 2000 higher than 728 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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