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NCT07447076 · ClinicalTrials.gov registry record · Phase 2
Study of Novel Therapies for Young People With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT)
A Phase 2 study, sponsored by Sabine Mueller, MD, PhD.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 29
- Enrollment target
NCT07447076: Recruiting Phase 2 study, sponsored by Sabine Mueller, MD, PhD.
NCT07447076 is a Phase 2 study that is actively recruiting participants, run by Sabine Mueller, MD, PhD. The registered enrollment target is 29 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07447076, a Phase 2 study, is actively recruiting participants, sponsored by Sabine Mueller, MD, PhD.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 29 participants
- Enrollment target
Study Summary
This is a multi-treatment arm study that will be conducted through the Pacific Pediatric Neuro-oncology Consortium (PNOC).The study will assess the safety and efficacy of novel therapies and combinatorial strategies for participants with recurrent or progressive ATRT.
Primary Outcome
Tolerability is defined as the proportion of participants receiving at least one dose of combination gemcitabine and paxalisib with a reported dose-limiting toxicity (DLT) during cycle 1 for all participants in Phase I.
Interventions
- PROCEDURE Magnetic resonance imaging (MRI)
- DRUG Gemcitabine
- DRUG Paxalisib
- PROCEDURE Blood Specimen Collection
- PROCEDURE Lumber Puncture
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2026-06-17 |
| Est. Completion | 2036-12-31 |
| Phase | Phase 2 |
What NCT07447076 shows while recruiting
NCT07447076 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 5 interventions - of which Magnetic resonance imaging (MRI) is the first listed.
NCT07447076 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07447076 about?
NCT07447076 is a clinical study titled "Study of Novel Therapies for Young People With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT)". This is a multi-treatment arm study that will be conducted through the Pacific Pediatric Neuro-oncology Consortium (PNOC).The study will assess the safety and efficacy of novel therapies and combinatorial strategies for participants with recurrent or progressive ATRT.
What is the current status of trial NCT07447076?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 29 participants. The study started on 2026-06-17. Estimated completion is 2036-12-31.
What interventions are being tested in trial NCT07447076?
The interventions under investigation include: Magnetic resonance imaging (MRI) (PROCEDURE), Gemcitabine (DRUG), Paxalisib (DRUG), Blood Specimen Collection (PROCEDURE), Lumber Puncture (PROCEDURE).
Who is sponsoring clinical trial NCT07447076?
This trial is sponsored by Sabine Mueller, MD, PhD, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07447076's enrollment target sits among peer trials
29 1669th of 2000 higher than 324 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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