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NCT07433023 · ClinicalTrials.gov registry record · Phase 2
tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
A Phase 2 study, sponsored by Shirley Ryan AbilityLab.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
NCT07433023: Recruiting Phase 2 study, sponsored by Shirley Ryan AbilityLab.
NCT07433023 is a Phase 2 study that is actively recruiting participants, run by Shirley Ryan AbilityLab. The registered enrollment target is 80 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07433023, a Phase 2 study, is actively recruiting participants, sponsored by Shirley Ryan AbilityLab.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
Study Summary
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy. Participants will complete a 16-week training program with weekly sessions of spinal stimulation and walking or activity-based training. Participants will also have the option to participate in a randomized control trial to investigate the impact of 5-Azacitidine combined with the spinal stimulation to further affect mobility outcomes.
Primary Outcome
For Aim 1 participants (GMFCS levels 1-3), an instrumented gait-mat will be used to assess spatiotemporal gait symmetry.
Interventions
- DRUG 5-Azacitidine
- DRUG Mannitol
- OTHER tSCS
- OTHER Functional Activity Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-05-28 |
| Est. Completion | 2029-01-01 |
| Phase | Phase 2 |
What NCT07433023 shows while recruiting
NCT07433023 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 4 interventions - of which 5-Azacitidine is the first listed.
NCT07433023 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07433023 about?
NCT07433023 is a clinical study titled "tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy". This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy. Participants will complete a 16-week training program with weekly sessions of spinal stimulation and walking or activity-based training. Participants will also have the...
What is the current status of trial NCT07433023?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2026-05-28. Estimated completion is 2029-01-01.
What interventions are being tested in trial NCT07433023?
The interventions under investigation include: 5-Azacitidine (DRUG), Mannitol (DRUG), tSCS (OTHER), Functional Activity Training (OTHER).
Who is sponsoring clinical trial NCT07433023?
This trial is sponsored by Shirley Ryan AbilityLab, which has 138 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07433023's enrollment target sits among peer trials
80 842nd of 2000 higher than 1,117 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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