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A Study to Learn About mRNA Vaccines Against Influenza in Adults
NCT07431853 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to learn about safety in participants taking the study vaccine (mRNA-based vaccine) and the ability of the study vaccine to trigger the body's immune response, targeting the flu virus (influenza virus). This study is seeking healthy participants 18 years of age or older. All participants in this study will receive only 1 dose in their arm, to deliver one of the experimental flu vaccines or one of the approved flu vaccines used for comparison. Participants will take part in this study for about 6 months, and participants will need to visit the study site at least 3 times. A blood sample will be taken at each of the 3 planned study visits and a swab from inside the nose will be taken at the first study visit.
Conditions Studied
Interventions
- BIOLOGICAL Vaccine Candidate #1
- BIOLOGICAL Vaccine Candidate #2
- BIOLOGICAL Vaccine Candidate #3
- BIOLOGICAL Vaccine Candidate #4
- BIOLOGICAL Vaccine Candidate #5
Study Locations (15)
Florida
- Indago Research & Health Center, Inc — Hialeah
- Palm Springs Community Health Center — Miami Lakes
Texas
- SMS Clinical Research LLC — Mesquite
- DM Clinical Research — Tomball
Alabama
- AMR Clinical — Mobile
California
- Diablo Clinical Research, LLC d/b/a Flourish Research — Walnut Creek
Connecticut
- Clinical Research Consulting, LLC — Milford
District of Columbia
- George Washington Medical Faculty Associates — Washington D.C.
Georgia
- Clinical Research Atlanta — Stockbridge
Hawaii
- East-West Medical Research Institute — Honolulu
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 770 participants |
| Start Date | 2026-02-23 |
| Est. Completion | 2027-06-22 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07431853
The ClinicalTrials.gov registry entry for NCT07431853 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 770 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Healthy Adults appearing as the primary indexed condition, and to 5 interventions — of which Vaccine Candidate #1 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07431853 reports 15 study locations spanning 13 distinct geographic areas — top geographies include Florida, Texas, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07431853 about?
NCT07431853 is a clinical study titled "A Study to Learn About mRNA Vaccines Against Influenza in Adults". The purpose of this study is to learn about safety in participants taking the study vaccine (mRNA-based vaccine) and the ability of the study vaccine to trigger the body's immune response, targeting the flu virus (influenza virus). This study is seeking healthy participants 18 years of age or older...
What is the current status of trial NCT07431853?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 770 participants. The study started on 2026-02-23. Estimated completion is 2027-06-22.
What conditions does trial NCT07431853 study?
This clinical trial studies the following conditions: Healthy Adults. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07431853?
The interventions under investigation include: Vaccine Candidate #1 (BIOLOGICAL), Vaccine Candidate #2 (BIOLOGICAL), Vaccine Candidate #3 (BIOLOGICAL), Vaccine Candidate #4 (BIOLOGICAL), Vaccine Candidate #5 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07431853?
This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07431853 being conducted?
This trial has 15 study locations across Alabama, California, Connecticut, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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