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NCT07305831 · ClinicalTrials.gov registry record · Phase 1
A Clinical Trial to Evaluate the Effect of Ulonivirine (MK-8507) on Heart Rhythm in Healthy Adults (MK-8507-012)
A Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.
- Active
- Registry status
- Phase 1
- Development phase
- 62
- Enrollment target
- 1
- Study location
NCT07305831: Active Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.
NCT07305831 is a Phase 1 study of Healthy that is active but no longer recruiting, run by Merck Sharp & Dohme. The registered enrollment target is 62 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07305831, a Phase 1 study of Healthy, is active but no longer recruiting, sponsored by Merck Sharp & Dohme.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 62 participants
- Enrollment target
- 1
- Study location
Study Summary
Researchers are looking for new treatments for HIV-1 (human immunodeficiency virus type 1) that are safe, well-tolerated, and can be taken less often. HIV-1 is the most common type of HIV, which is a virus that attacks cells of the immune system. Ulonivirine (MK-8507) is a study medicine designed to treat HIV-1 The goal of this study is to learn if ulonivirine does not increase the QT interval (a measure of heart rhythm on an electrocardiogram) above a certain amount. Researchers also want to learn what happens to the amount of ulonivirine in a healthy person's body over time.
Primary Outcome
Change from baseline in QTc following ulonivirine administration will be reported.
Conditions Studied
Interventions
- DRUG Moxifloxacin
- DRUG Ulonivirine
- DRUG Ulonivirine Placebo
- DRUG Moxifloxacin Placebo
Study Locations (1)
Texas
- ICON Early Phase Services (0001) - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2026-01-22 |
| Est. Completion | 2026-04-09 |
| Phase | Phase 1 |
What the registry record for NCT07305831 still lists
NCT07305831 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 4 interventions - of which Moxifloxacin is the first listed.
NCT07305831 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT07305831 about?
NCT07305831 is a clinical study titled "A Clinical Trial to Evaluate the Effect of Ulonivirine (MK-8507) on Heart Rhythm in Healthy Adults (MK-8507-012)". Researchers are looking for new treatments for HIV-1 (human immunodeficiency virus type 1) that are safe, well-tolerated, and can be taken less often. HIV-1 is the most common type of HIV, which is a virus that attacks cells of the immune system. Ulonivirine (MK-8507) is a study medicine designed t...
What is the current status of trial NCT07305831?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 62 participants. The study started on 2026-01-22. Estimated completion is 2026-04-09.
What conditions does trial NCT07305831 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT07305831?
The interventions under investigation include: Moxifloxacin (DRUG), Ulonivirine (DRUG), Ulonivirine Placebo (DRUG), Moxifloxacin Placebo (DRUG).
Who is sponsoring clinical trial NCT07305831?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07305831 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07305831's enrollment target sits among peer trials
62 361st of 1090 higher than 728 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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