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NCT07305818 · ClinicalTrials.gov registry record · Phase 1

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

A Phase 1 study of Graves Disease, sponsored by Merida Biosciences.

Recruiting
Registry status
Phase 1
Development phase
100
Enrollment target
3
Study locations

NCT07305818 is a Phase 1 study of Graves Disease that is actively recruiting participants, run by Merida Biosciences. The registered enrollment target is 100 participants, below the 301-participant average among 11 other Graves Disease trials with a reported enrollment target (67% lower). The trial reports 3 study locations across 3 states.

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The verdict

NCT07305818, a Phase 1 study of Graves Disease, is actively recruiting participants, sponsored by Merida Biosciences.

RECRUITING
Registry status
Phase 1
Development phase
100 participants
Enrollment target
3
Study locations

Study Summary

The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease. The study drug will be administered either intravenously (into a vein in the arm) or subcutaneously (under the skin). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body.

Conditions Studied

Graves Disease

Interventions

  • BIOLOGICAL MER511 (IV)
  • BIOLOGICAL Placebo comparator (IV)
  • BIOLOGICAL MER511 (SC)
  • BIOLOGICAL Placebo comparator (SC)
  • BIOLOGICAL MER511 (SC) for MAD

Study Locations (3)

Arizona

  • Site # 1103 - Phoenix

Florida

  • Site # 1101 - Hollywood

Texas

  • Site # 1105 - Webster

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2025-12-19
Est. Completion 2028-07-24
Phase Phase 1

Sponsor

Merida Biosciences

1 total trials

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What the Registry Record Tells You About NCT07305818

The ClinicalTrials.gov registry entry for NCT07305818 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 301-participant average among 11 other Graves Disease trials with a reported enrollment target (67% lower). The listed sponsor is Merida Biosciences, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Graves Disease appearing as the primary indexed condition, and to 5 interventions - of which MER511 (IV) is the first listed.

NCT07305818 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Arizona, Florida, Texas.

Frequently Asked Questions

What is clinical trial NCT07305818 about?

NCT07305818 is a clinical study titled "NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease". The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease. The study drug will be administered either intravenously (into a vein in the arm) or subcutaneously (under the skin). Blood tests will be performed to investigat...

What is the current status of trial NCT07305818?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2025-12-19. Estimated completion is 2028-07-24.

What conditions does trial NCT07305818 study?

This clinical trial studies the following conditions: Graves Disease.

What interventions are being tested in trial NCT07305818?

The interventions under investigation include: MER511 (IV) (BIOLOGICAL), Placebo comparator (IV) (BIOLOGICAL), MER511 (SC) (BIOLOGICAL), Placebo comparator (SC) (BIOLOGICAL), MER511 (SC) for MAD (BIOLOGICAL).

Who is sponsoring clinical trial NCT07305818?

This trial is sponsored by Merida Biosciences, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07305818 being conducted?

This trial has 3 study locations across Arizona, Florida, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.