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NCT07298447 · ClinicalTrials.gov registry record · Phase 3

Donidalorsen Treatment in Children With Hereditary Angioedema

A Phase 3 study of Hereditary Angioedema (HAE), sponsored by Ionis Pharmaceuticals.

Recruiting
Registry status
Phase 3
Development phase
20
Enrollment target
3
Study locations

NCT07298447 is a Phase 3 study of Hereditary Angioedema (HAE) that is actively recruiting participants, run by Ionis Pharmaceuticals. The registered enrollment target is 20 participants, below the 65-participant average among 7 other Hereditary Angioedema (HAE) trials with a reported enrollment target (69% lower). The trial reports 3 study locations across 3 states.

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The verdict

NCT07298447, a Phase 3 study of Hereditary Angioedema (HAE), is actively recruiting participants, sponsored by Ionis Pharmaceuticals.

RECRUITING
Registry status
Phase 3
Development phase
20 participants
Enrollment target
3
Study locations

Study Summary

The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of donidalorsen in pediatric participants with hereditary angioedema (HAE) Type I (HAE-1) or Type II (HAE-2).

Conditions Studied

Hereditary Angioedema (HAE)

Interventions

  • DRUG Donidalorsen

Study Locations (3)

California

  • Ionis Investigative Site - Santa Monica

Missouri

  • Ionis Investigative Site - St Louis

Ohio

  • Ionis Investigative Site - Cincinnati

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2026-07
Est. Completion 2029-06
Phase Phase 3

Sponsor

Ionis Pharmaceuticals

76 total trials

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What the Registry Record Tells You About NCT07298447

The ClinicalTrials.gov registry entry for NCT07298447 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 65-participant average among 7 other Hereditary Angioedema (HAE) trials with a reported enrollment target (69% lower). The listed sponsor is Ionis Pharmaceuticals, which has 76 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Hereditary Angioedema (HAE) appearing as the primary indexed condition, and to 1 intervention - of which Donidalorsen is the first listed.

NCT07298447 reports 3 study locations spanning 3 distinct geographic areas - top geographies include California, Missouri, Ohio.

Frequently Asked Questions

What is clinical trial NCT07298447 about?

NCT07298447 is a clinical study titled "Donidalorsen Treatment in Children With Hereditary Angioedema". The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of donidalorsen in pediatric participants with hereditary angioedema (HAE) Type I (HAE-1) or Type II (HAE-2).

What is the current status of trial NCT07298447?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 20 participants. The study started on 2026-07. Estimated completion is 2029-06.

What conditions does trial NCT07298447 study?

This clinical trial studies the following conditions: Hereditary Angioedema (HAE).

What interventions are being tested in trial NCT07298447?

The interventions under investigation include: Donidalorsen (DRUG).

Who is sponsoring clinical trial NCT07298447?

This trial is sponsored by Ionis Pharmaceuticals, which has 76 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07298447 being conducted?

This trial has 3 study locations across California, Missouri, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.