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RECRUITING Phase 3

Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

NCT06679881 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 3, multicenter, long-term, open-label study to evaluate the safety and efficacy of once-daily orally administered deucrictibant extended-release tablet for prophylaxis to prevent angioedema attacks in participants aged ≥12 years with Hereditary Angioedema

Interventions

  • DRUG Deucrictibant

Study Locations (20)

Other

  • Study Site — Melbourne
  • Study Site — Melbourne
  • Study Site — Perth
  • Study Site — Vienna
  • Study Site — Sofia
  • Study Site — Montreal
  • Study Site — Berlin
  • Study Site — Frankfurt
  • Study Site — Hong Kong
  • Study Site — Dublin
  • Study Site — Padua
  • Study Site — Krakow
  • Study Site — Cape Town
  • Study Site — Daegu
  • Study Site — Seoul
  • Study Site — Barcelona
  • Study Site — Brighton

California

  • Study Site — Santa Monica
  • Study Site — Walnut Creek

Missouri

  • Study Site — St Louis

Trial Details

FieldValue
Enrollment Target 170 participants
Start Date 2025-02-01
Est. Completion 2028-12
Phase Phase 3

Sponsor

Pharvaris Netherlands B.V.

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06679881

The ClinicalTrials.gov registry entry for NCT06679881 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 170 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pharvaris Netherlands B.V., which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hereditary Angioedema (HAE) appearing as the primary indexed condition, and to 1 intervention — of which Deucrictibant is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06679881 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Other, California, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06679881 about?

NCT06679881 is a clinical study titled "Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE". This is a Phase 3, multicenter, long-term, open-label study to evaluate the safety and efficacy of once-daily orally administered deucrictibant extended-release tablet for prophylaxis to prevent angioedema attacks in participants aged ≥12 years with Hereditary Angioedema

What is the current status of trial NCT06679881?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 170 participants. The study started on 2025-02-01. Estimated completion is 2028-12.

What conditions does trial NCT06679881 study?

This clinical trial studies the following conditions: Hereditary Angioedema (HAE). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06679881?

The interventions under investigation include: Deucrictibant (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06679881?

This trial is sponsored by Pharvaris Netherlands B.V., which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06679881 being conducted?

This trial has 20 study locations across California, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial