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NCT07265271 · ClinicalTrials.gov registry record
A Cell-free tsRNA Signature for Early Detection of Hepatocellular Carcinoma
A clinical trial of Hepatocellular Carcinoma (HCC), sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- 600
- Enrollment target
- 1
- Study location
NCT07265271: Recruiting study of Hepatocellular Carcinoma (HCC), sponsored by City of Hope Medical Center.
NCT07265271 is a study of Hepatocellular Carcinoma (HCC) that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 600 participants, above the 311-participant average among 15 other Hepatocellular Carcinoma (HCC) trials with a reported enrollment target (93% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07265271, a study of Hepatocellular Carcinoma (HCC), is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- 600 participants
- Enrollment target
- 1
- Study location
Study Summary
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited. This study seeks to develop a cell-free tsRNA (cf-tsRNA)-based liquid biopsy assay for accurate detection of early-stage HCC.
Primary Outcome
To evaluate the diagnostic accuracy of the model for distinguishing patients with hepatocellular carcinoma from chronic liver disease and healthy controls, as assessed by the area under the operating characteristic curve (AUC), sensitivity, and specificity.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Small RNA sequence
- DIAGNOSTIC_TEST Rt-qPCR
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2025-01-15 |
| Est. Completion | 2026-06-18 |
What NCT07265271 shows while recruiting
NCT07265271 is an observational study that tracks outcomes without assigning an intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, above the 311-participant average among 15 other Hepatocellular Carcinoma (HCC) trials with a reported enrollment target (93% higher).
The record links to 1 condition, with Hepatocellular Carcinoma (HCC) appearing as the primary indexed condition, and to 2 interventions - of which Small RNA sequence is the first listed.
NCT07265271 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07265271 about?
NCT07265271 is a clinical study titled "A Cell-free tsRNA Signature for Early Detection of Hepatocellular Carcinoma". Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited. This study seeks to develop a cell-free tsRNA (cf-tsRNA)-based liquid biopsy assay ...
What is the current status of trial NCT07265271?
This trial is currently recruiting. The enrollment target is 600 participants. The study started on 2025-01-15. Estimated completion is 2026-06-18.
What conditions does trial NCT07265271 study?
This clinical trial studies the following conditions: Hepatocellular Carcinoma (HCC).
What interventions are being tested in trial NCT07265271?
The interventions under investigation include: Small RNA sequence (DIAGNOSTIC_TEST), Rt-qPCR (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07265271?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07265271 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07265271's enrollment target sits among peer trials
600 4th of 15 higher than 12 of 15 other Hepatocellular Carcinoma (HCC) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hepatocellular Carcinoma (HCC) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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