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NCT07244809 · ClinicalTrials.gov registry record · NA
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
A NA study of Oxidative Stress and Mitochondrial Function, sponsored by University of Iowa.
- Recruiting
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT07244809 is a NA study of Oxidative Stress and Mitochondrial Function that is actively recruiting participants, run by University of Iowa. The registered enrollment target is 300 participants, above the 78-participant average among 36 other Oxidative Stress trials with a reported enrollment target (285% higher). The trial reports 1 study location across 1 state.
The verdict
NCT07244809, a NA study of Oxidative Stress and Mitochondrial Function, is actively recruiting participants, sponsored by University of Iowa.
- RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Greater exposure to ACEs are associated with greater increases in the risk of cardiovascular diseases and death. Our laboratory has previously observed that vascular function is disrupted in young adults with prior ACE exposure, even though these individuals appear to be healthy clinically (i.e., no classic clinical cardiovascular disease risk factors). There is a need to identify and understand the biological mechanisms underlying these vascular impairments to inform effective interventions to reduce cardiovascular risks the millions of individuals affected by ACEs. The body's response to stress is coordinated across various systems, all of which depend on energy supplied by mitochondria (often referred to as the "powerhouse of cells"). Based on new evidence across multiple physiological systems from our team, our overarching hypothesis is that disruption of mitochondrial function contributes to cardiovascular impairments among young adults with ACEs. Here we propose the initial pilot work necessary to begin to understand these associations, which will directly inform identification of individuals who may be most vulnerable to stress-related cardiovascular risk and the development of interventions to promote cardiovascular-stress resilience. Our aims are to: 1. Determine whether mitochondrial oxidative stress contributes to impaired vascular function among young adults who experienced early life adversity. 2. Determine whether reducing mitochondrial oxidative stress improves the cellular stress and integrated cardiovascular response to laboratory-based psychosocial stress among young adults who experienced early life adversity.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT Mitoquinone mesylate (MitoQ)
Study Locations (1)
Iowa
- Integrative Laboratory of Applied Physiology and Lifestyle Medicine - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2025-10-13 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07244809
The ClinicalTrials.gov registry entry for NCT07244809 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 78-participant average among 36 other Oxidative Stress trials with a reported enrollment target (285% higher). The listed sponsor is University of Iowa, which has 228 total studies on file at ClinicalTrials.gov.
The record links to 6 conditions, with Oxidative Stress appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07244809 reports 1 study location spanning 1 distinct geographic area - top geographies include Iowa.
Frequently Asked Questions
What is clinical trial NCT07244809 about?
NCT07244809 is a clinical study titled "Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity". Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Greater exposure to ACEs are associated with greater increases in the risk of cardiovascular diseases and death. Our labora...
What is the current status of trial NCT07244809?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2025-10-13. Estimated completion is 2026-12-31.
What conditions does trial NCT07244809 study?
This clinical trial studies the following conditions: Oxidative Stress, Mitochondrial Function, Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury.
What interventions are being tested in trial NCT07244809?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Mitoquinone mesylate (MitoQ) (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07244809?
This trial is sponsored by University of Iowa, which has 228 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07244809 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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