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NCT07232589 · ClinicalTrials.gov registry record · Phase 1
A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)
A Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT07232589: Recruiting Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.
NCT07232589 is a Phase 1 study of Healthy that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 24 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07232589, a Phase 1 study of Healthy, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of the study is to learn what happens to levels of nemtabrutinib (MK-1026) in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called diltiazem.
Primary Outcome
Blood samples will be collected to determine the AUC0-inf of nemtabrutinib.
Conditions Studied
Interventions
- DRUG Nemtabrutinib
- DRUG Diltiazem
Study Locations (1)
Wisconsin
- Fortea CRU Madison ( Site 0001) - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-12-08 |
| Est. Completion | 2026-04-24 |
| Phase | Phase 1 |
What NCT07232589 shows while recruiting
NCT07232589 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 2 interventions - of which Nemtabrutinib is the first listed.
NCT07232589 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT07232589 about?
NCT07232589 is a clinical study titled "A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)". The goal of the study is to learn what happens to levels of nemtabrutinib (MK-1026) in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called diltiazem.
What is the current status of trial NCT07232589?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-12-08. Estimated completion is 2026-04-24.
What conditions does trial NCT07232589 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT07232589?
The interventions under investigation include: Nemtabrutinib (DRUG), Diltiazem (DRUG).
Who is sponsoring clinical trial NCT07232589?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07232589 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07232589's enrollment target sits among peer trials
24 791st of 1090 higher than 254 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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