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NCT07232589 · ClinicalTrials.gov registry record · Phase 1

A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)

A Phase 1 study of Healthy, sponsored by Merck Sharp & Dohme.

Recruiting
Registry status
Phase 1
Development phase
24
Enrollment target
1
Study location

NCT07232589 is a Phase 1 study of Healthy that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 24 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07232589, a Phase 1 study of Healthy, is actively recruiting participants, sponsored by Merck Sharp & Dohme.

RECRUITING
Registry status
Phase 1
Development phase
24 participants
Enrollment target
1
Study location

Study Summary

The goal of the study is to learn what happens to levels of nemtabrutinib (MK-1026) in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called diltiazem.

Conditions Studied

Healthy

Interventions

  • DRUG Nemtabrutinib
  • DRUG Diltiazem

Study Locations (1)

Wisconsin

  • Fortea CRU Madison ( Site 0001) - Madison

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2025-12-08
Est. Completion 2026-04-24
Phase Phase 1

Sponsor

Merck Sharp & Dohme

558 total trials

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What the Registry Record Tells You About NCT07232589

The ClinicalTrials.gov registry entry for NCT07232589 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The listed sponsor is Merck Sharp & Dohme, which has 558 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 2 interventions - of which Nemtabrutinib is the first listed.

NCT07232589 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.

Frequently Asked Questions

What is clinical trial NCT07232589 about?

NCT07232589 is a clinical study titled "A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)". The goal of the study is to learn what happens to levels of nemtabrutinib (MK-1026) in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called diltiazem.

What is the current status of trial NCT07232589?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-12-08. Estimated completion is 2026-04-24.

What conditions does trial NCT07232589 study?

This clinical trial studies the following conditions: Healthy.

What interventions are being tested in trial NCT07232589?

The interventions under investigation include: Nemtabrutinib (DRUG), Diltiazem (DRUG).

Who is sponsoring clinical trial NCT07232589?

This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07232589 being conducted?

This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.