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NCT07227649 · ClinicalTrials.gov registry record · Phase 2
NAC-REPAIR for Post-surgical Pain
A Phase 2 study, sponsored by University of Arizona.
- Not yet
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
NCT07227649 is a Phase 2 study that has not yet begun recruiting, run by University of Arizona. The registered enrollment target is 80 participants.
The verdict
NCT07227649, a Phase 2 study, has not yet begun recruiting, sponsored by University of Arizona.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
Study Summary
This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, adherence, follow-up), estimate NAC vs placebo effects on pain, function, and opioid consumption, and characterize inflammatory signatures that may predict response. Methods: a single-site, double-blind, 1:1 randomized trial (N≈80) comparing NAC 1,200 mg twice daily for 14 days (starting pre-op) vs matching placebo; daily e-diaries for POD0-14; standardized outcomes (PROMIS Pain Interference; QuickDASH or FAAM; PGIC; opioid MME); and small blood draws pre-surgery and at two follow-up visits for cytokine profiling.
Interventions
- DRUG NAC 0mg/day (Placebo)
- DRUG NAC
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-01-15 |
| Est. Completion | 2027-07-15 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07227649
The ClinicalTrials.gov registry entry for NCT07227649 describes a study currently listed as not yet recruiting, categorized as Phase 2. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Arizona, which has 349 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which NAC 0mg/day (Placebo) is the first listed.
NCT07227649 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07227649 about?
NCT07227649 is a clinical study titled "NAC-REPAIR for Post-surgical Pain". This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, ...
What is the current status of trial NCT07227649?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2026-01-15. Estimated completion is 2027-07-15.
What interventions are being tested in trial NCT07227649?
The interventions under investigation include: NAC 0mg/day (Placebo) (DRUG), NAC (DRUG).
Who is sponsoring clinical trial NCT07227649?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
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