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NCT07227649 · ClinicalTrials.gov registry record · Phase 2
NAC-REPAIR for Post-surgical Pain
A Phase 2 study, sponsored by University of Arizona.
- Not yet
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
NCT07227649: Clinical Trial Phase 2 study, sponsored by University of Arizona.
NCT07227649 is a Phase 2 study that has not yet begun recruiting, run by University of Arizona. The registered enrollment target is 80 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07227649, a Phase 2 study, has not yet begun recruiting, sponsored by University of Arizona.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
Study Summary
This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, adherence, follow-up), estimate NAC vs placebo effects on pain, function, and opioid consumption, and characterize inflammatory signatures that may predict response. Methods: a single-site, double-blind, 1:1 randomized trial (N≈80) comparing NAC 1,200 mg twice daily for 14 days (starting pre-op) vs matching placebo; daily e-diaries for POD0-14; standardized outcomes (PROMIS Pain Interference; QuickDASH or FAAM; PGIC; opioid MME); and small blood draws pre-surgery and at two follow-up visits for cytokine profiling.
Primary Outcome
Patient-Reported Outcomes Measurement Information System - Pain Interference T-score metric: mean = 50, SD = 10 Higher scores = worse outcome (greater pain interference with daily activities, social, cognitive, emotional, and physical functioning)
Interventions
- DRUG NAC 0mg/day (Placebo)
- DRUG NAC
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-01-15 |
| Est. Completion | 2027-07-15 |
| Phase | Phase 2 |
What is known before NCT07227649 opens enrollment
NCT07227649 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 2 interventions - of which NAC 0mg/day (Placebo) is the first listed.
NCT07227649 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07227649 about?
NCT07227649 is a clinical study titled "NAC-REPAIR for Post-surgical Pain". This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, ...
What is the current status of trial NCT07227649?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2026-01-15. Estimated completion is 2027-07-15.
What interventions are being tested in trial NCT07227649?
The interventions under investigation include: NAC 0mg/day (Placebo) (DRUG), NAC (DRUG).
Who is sponsoring clinical trial NCT07227649?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07227649's enrollment target sits among peer trials
80 842nd of 2000 higher than 1,117 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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