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NCT07224841 · ClinicalTrials.gov registry record
Development of a cfDNA 5mC/5hmC-based Biomarker Panel to Predict Targeted Therapy Efficacy in mCRC
A clinical trial of CRC, Colorectal Cancer, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- 500
- Enrollment target
- 1
- Study location
NCT07224841 is a study of CRC, Colorectal Cancer that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 500 participants, above the 271-participant average among 10 other CRC, Colorectal Cancer trials with a reported enrollment target (85% higher). The trial reports 1 study location across 1 state.
The verdict
NCT07224841, a study of CRC, Colorectal Cancer, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
The EpiDRIVE study aims to identify cfDNA-based epigenetic determinants of response in metastatic colorectal cancer (mCRC) patients treated with EGFR- or VEGF-targeted therapy. By integrating 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) profiling, this study seeks to develop a predictive biomarker panel capable of differentiating responders from non-responders to targeted therapy.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST cfDNA 5mC/5hmC Sequencing (EpiDRIVE Discovery Phase)
- DIAGNOSTIC_TEST EpiDRIVE Assay (Targeted Sequencing / qPCR Validation)
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2024-06-21 |
| Est. Completion | 2026-06-18 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07224841
The ClinicalTrials.gov registry entry for NCT07224841 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 500 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 271-participant average among 10 other CRC, Colorectal Cancer trials with a reported enrollment target (85% higher). The listed sponsor is City of Hope Medical Center, which has 582 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with CRC, Colorectal Cancer appearing as the primary indexed condition, and to 2 interventions - of which cfDNA 5mC/5hmC Sequencing (EpiDRIVE Discovery Phase) is the first listed.
NCT07224841 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT07224841 about?
NCT07224841 is a clinical study titled "Development of a cfDNA 5mC/5hmC-based Biomarker Panel to Predict Targeted Therapy Efficacy in mCRC". The EpiDRIVE study aims to identify cfDNA-based epigenetic determinants of response in metastatic colorectal cancer (mCRC) patients treated with EGFR- or VEGF-targeted therapy. By integrating 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) profiling, this study seeks to develop a predicti...
What is the current status of trial NCT07224841?
This trial is currently recruiting. The enrollment target is 500 participants. The study started on 2024-06-21. Estimated completion is 2026-06-18.
What conditions does trial NCT07224841 study?
This clinical trial studies the following conditions: CRC, Colorectal Cancer.
What interventions are being tested in trial NCT07224841?
The interventions under investigation include: cfDNA 5mC/5hmC Sequencing (EpiDRIVE Discovery Phase) (DIAGNOSTIC_TEST), EpiDRIVE Assay (Targeted Sequencing / qPCR Validation) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07224841?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07224841 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.