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NCT07223515 · ClinicalTrials.gov registry record
HEAL-4: Real-World Effectiveness of 4 Amniotic Allografts Adjunctive to Standard Care in DFU, VLU, and PU
A clinical trial of Diabetic Foot Ulcer (DFU) and Venous Leg Ulcers (VLUs), sponsored by Dynamic Medical Services dba Acesso Biologics.
- Active
- Registry status
- 2,000
- Enrollment target
- 2
- Study locations
NCT07223515: Active study of Diabetic Foot Ulcer (DFU) and Venous Leg Ulcers (VLUs), sponsored by Dynamic Medical Services dba Acesso Biologics.
NCT07223515 is a study of Diabetic Foot Ulcer (DFU) and Venous Leg Ulcers (VLUs) that is active but no longer recruiting, run by Dynamic Medical Services dba Acesso Biologics. The registered enrollment target is 2,000 participants, above the 364-participant average among 13 other Diabetic Foot Ulcer (DFU) trials with a reported enrollment target (449% higher). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07223515, a study of Diabetic Foot Ulcer (DFU) and Venous Leg Ulcers (VLUs), is active but no longer recruiting, sponsored by Dynamic Medical Services dba Acesso Biologics.
- ACTIVE NOT RECRUITING
- Registry status
- 2,000 participants
- Enrollment target
- 2
- Study locations
Study Summary
This retrospective multi-site observational cohort study uses electronic health records (EHR) from U.S. wound care centers to evaluate the effectiveness of four amniotic membrane allografts (Acesso DL, Acesso TL, Neostim DL, Neostim TL) when added to standard wound care for diabetic foot ulcers (DFU), venous leg ulcers (VLU), and pressure ulcers (PU). The primary endpoint is complete wound closure by 12 weeks. Secondary outcomes include time-to-closure, ≥50% wound-area reduction at 4 weeks, wound-related complications (infection, hospitalization, emergency department visits, and major/minor amputation).
Primary Outcome
Proportion of index wounds with 100% epithelialization, no drainage or dressings; confirmation on ≥1 follow-up within 60 days
Conditions Studied
Study Locations (2)
Michigan
- Optalis - Novi
Tennessee
- ProCure Health - Murfreesboro
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,000 participants |
| Start Date | 2025-10-24 |
| Est. Completion | 2025-11 |
What the registry record for NCT07223515 still lists
NCT07223515 is an observational study that tracks outcomes without assigning an intervention. Its 2,000 participants enrollment target places it among the larger protocols in the corpus, above the 364-participant average among 13 other Diabetic Foot Ulcer (DFU) trials with a reported enrollment target (449% higher).
The record links to 3 conditions, with Diabetic Foot Ulcer (DFU) appearing as the primary indexed condition, and to 0 interventions.
NCT07223515 reports a single indexed study location in Michigan, Tennessee.
Frequently Asked Questions
What is clinical trial NCT07223515 about?
NCT07223515 is a clinical study titled "HEAL-4: Real-World Effectiveness of 4 Amniotic Allografts Adjunctive to Standard Care in DFU, VLU, and PU". This retrospective multi-site observational cohort study uses electronic health records (EHR) from U.S. wound care centers to evaluate the effectiveness of four amniotic membrane allografts (Acesso DL, Acesso TL, Neostim DL, Neostim TL) when added to standard wound care for diabetic foot ulcers (DFU...
What is the current status of trial NCT07223515?
This trial is currently active not recruiting. The enrollment target is 2,000 participants. The study started on 2025-10-24. Estimated completion is 2025-11.
What conditions does trial NCT07223515 study?
This clinical trial studies the following conditions: Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs), Pressure Ulcers, Bedsores, Decubitus Ulcer.
Who is sponsoring clinical trial NCT07223515?
This trial is sponsored by Dynamic Medical Services dba Acesso Biologics, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07223515 being conducted?
This trial has 2 study locations across Michigan, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetic Foot Ulcer (DFU)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07223515's enrollment target sits among peer trials
2,000 2nd of 13 the highest of 13 other Diabetic Foot Ulcer (DFU) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetic Foot Ulcer (DFU) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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