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RECRUITING Phase 2

A Study of V940/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

NCT07221474 · View on ClinicalTrials.gov ↗

Study Summary

Researchers want to know if V940 (the study treatment) given with pembrolizumab and chemotherapy can treat metastatic treatment-naive squamous non-small cell lung cancer (NSCLC). V940 is designed to help a person's immune system attack their specific cancer. The goal of this study is to learn if people who receive V940 with pembrolizumab and chemotherapy live longer overall and without the cancer growing or spreading compared to people who receive placebo with pembrolizumab and chemotherapy. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of the study treatment.

Interventions

  • BIOLOGICAL Pembrolizumab
  • DRUG Carboplatin
  • DRUG Paclitaxel
  • BIOLOGICAL V940
  • DRUG Nab-paclitaxel

Study Locations (20)

Other

  • Asan Medical Center ( Site 0503) — Seoul
  • Samsung Medical Center ( Site 0502) — Seoul
  • National Cheng Kung University Hospital ( Site 0601) — Tainan
  • Mackay Memorial Hospital ( Site 0604) — Taipei

Buenos Aires

  • Instituto Alexander Fleming ( Site 0201) — Ciudad Autonoma de Buenos Aires
  • Instituto de Investigaciones Clínicas Mar del Plata ( Site 0205) — Mar del Plata

Santa Fe Province

  • Fundacion Estudios Clinicos ( Site 0207) — Rosario
  • Sanatorio Parque ( Site 0203) — Rosario

Region M. de Santiago

  • Centro de Estudios Clínicos SAGA ( Site 0307) — Santiago
  • Bradfordhill ( Site 0301) — Santiago

Kyonggi-do

  • National Cancer Center ( Site 0504) — Goyang-si
  • Seoul National University Bundang Hospital ( Site 0500) — Seongnam-si

New Jersey

  • Valley Health Systems - Ridgewood Campus ( Site 0010) — Paramus

Ohio

  • Cleveland Clinic - Ohio ( Site 0016) — Cleveland

Tennessee

  • Tennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 9000) — Nashville

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2025-12-12
Est. Completion 2031-05-06
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07221474

The ClinicalTrials.gov registry entry for NCT07221474 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Squamous Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07221474 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Buenos Aires, Santa Fe Province. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07221474 about?

NCT07221474 is a clinical study titled "A Study of V940/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)". Researchers want to know if V940 (the study treatment) given with pembrolizumab and chemotherapy can treat metastatic treatment-naive squamous non-small cell lung cancer (NSCLC). V940 is designed to help a person's immune system attack their specific cancer. The goal of this study is to learn if pe...

What is the current status of trial NCT07221474?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2025-12-12. Estimated completion is 2031-05-06.

What conditions does trial NCT07221474 study?

This clinical trial studies the following conditions: Squamous Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07221474?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Carboplatin (DRUG), Paclitaxel (DRUG), V940 (BIOLOGICAL), Nab-paclitaxel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07221474?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07221474 being conducted?

This trial has 20 study locations across New Jersey, Ohio, Tennessee, Virginia, Buenos Aires. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial