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NCT07216781 · ClinicalTrials.gov registry record · Phase 1
Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans
A Phase 1 study of Healthy Adults, sponsored by Minicircle.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 2
- Study locations
NCT07216781 is a Phase 1 study of Healthy Adults that is actively recruiting participants, run by Minicircle. The registered enrollment target is 24 participants, below the 86-participant average among 33 other Healthy Adults trials with a reported enrollment target (72% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT07216781, a Phase 1 study of Healthy Adults, is actively recruiting participants, sponsored by Minicircle.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
Conditions Studied
Interventions
- GENETIC Injectable Plasmid Klotho Gene Therapy
Study Locations (2)
Texas
- Apeiron Center - Austin
Bay Islands
- GARM Clinic - Roatán
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-10-06 |
| Est. Completion | 2026-08 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07216781
The ClinicalTrials.gov registry entry for NCT07216781 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 86-participant average among 33 other Healthy Adults trials with a reported enrollment target (72% lower). The listed sponsor is Minicircle, which has 2 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy Adults appearing as the primary indexed condition, and to 1 intervention - of which Injectable Plasmid Klotho Gene Therapy is the first listed.
NCT07216781 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Texas, Bay Islands.
Frequently Asked Questions
What is clinical trial NCT07216781 about?
NCT07216781 is a clinical study titled "Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans". The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
What is the current status of trial NCT07216781?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-10-06. Estimated completion is 2026-08.
What conditions does trial NCT07216781 study?
This clinical trial studies the following conditions: Healthy Adults.
What interventions are being tested in trial NCT07216781?
The interventions under investigation include: Injectable Plasmid Klotho Gene Therapy (GENETIC).
Who is sponsoring clinical trial NCT07216781?
This trial is sponsored by Minicircle, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07216781 being conducted?
This trial has 2 study locations across Texas, Bay Islands. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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