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NCT07215390 · ClinicalTrials.gov registry record · Phase 2
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio
A Phase 2 study of Geographic Atrophy Secondary to Age-related Macular Degeneration, sponsored by Apellis Pharmaceuticals.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 240
- Enrollment target
- 20
- Study locations
NCT07215390 is a Phase 2 study of Geographic Atrophy Secondary to Age-related Macular Degeneration that is actively recruiting participants, run by Apellis Pharmaceuticals. The registered enrollment target is 240 participants, above the 166-participant average among 4 other Geographic Atrophy Secondary to Age-related Macular Degeneration trials with a reported enrollment target (45% higher). The trial reports 20 study locations across 11 states.
The verdict
NCT07215390, a Phase 2 study of Geographic Atrophy Secondary to Age-related Macular Degeneration, is actively recruiting participants, sponsored by Apellis Pharmaceuticals.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 240 participants
- Enrollment target
- 20
- Study locations
Study Summary
A Phase 2, Randomized, Placebo-controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL-3007 in Combination with Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed with Geographic Atrophy Secondary to Age-Related Macular Degeneration
Conditions Studied
Interventions
- DRUG APL-3007, pegcetacoplan (APL-2)
- OTHER Placebo, Syfovre
Study Locations (20)
California
- California Retina Consultants (CRC) - Bakersfield Office - Bakersfield
- The Retina Partners - Encino - Encino
- Retina Consultants of Orange County - Fullerton Office - Fullerton
- Salehi Retina Institute, Inc dba Retina Associate or Southern California (01034) - Huntington Beach
- Retina Consultants San Diego - Poway
- Orange County Retina Medical Group - Santa Ana
- Bay Area Retina Associates - Walnut Creek - Walnut Creek
Florida
- Florida Retina Institute - Orlando (01053) - Orlando
- Retina Specialty Institute - Pensacola - Pensacola
- Retina Vitreous Associates of Florida (RVA) - Saint Petersburg - St. Petersburg
Arizona
- Barnet Dulaney Perkins Eye Center (01018) - Mesa
- Associated Retina Consultants - Phoenix - Phoenix
Colorado
- Advanced Vision Research Institute - Longmont
Georgia
- Southeast Retina Center - Augusta
Illinois
- Illinois Retina Associates, S.C. - Oak Park (01061) - Oak Park
Indiana
- Retina Consultants P.C. - Indianapolis
Louisiana
- Retina Associates New Orleans - Jefferson Parish Location - Metairie
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-06-23 |
| Est. Completion | 2027-11 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07215390
The ClinicalTrials.gov registry entry for NCT07215390 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 166-participant average among 4 other Geographic Atrophy Secondary to Age-related Macular Degeneration trials with a reported enrollment target (45% higher). The listed sponsor is Apellis Pharmaceuticals, which has 21 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Geographic Atrophy Secondary to Age-related Macular Degeneration appearing as the primary indexed condition, and to 2 interventions - of which APL-3007, pegcetacoplan (APL-2) is the first listed.
NCT07215390 reports 20 study locations spanning 11 distinct geographic areas - top geographies include California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT07215390 about?
NCT07215390 is a clinical study titled "A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio". A Phase 2, Randomized, Placebo-controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL-3007 in Combination with Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed with Geographic Atrophy Secondary to Age-Related Macular Degeneratio...
What is the current status of trial NCT07215390?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-06-23. Estimated completion is 2027-11.
What conditions does trial NCT07215390 study?
This clinical trial studies the following conditions: Geographic Atrophy Secondary to Age-related Macular Degeneration.
What interventions are being tested in trial NCT07215390?
The interventions under investigation include: APL-3007, pegcetacoplan (APL-2) (DRUG), Placebo, Syfovre (OTHER).
Who is sponsoring clinical trial NCT07215390?
This trial is sponsored by Apellis Pharmaceuticals, which has 21 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07215390 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Read our methodology - how this data is sourced, computed, and verified.
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