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RECRUITING Phase 2

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

NCT06990269 · View on ClinicalTrials.gov ↗

Study Summary

Phase 2 study is designed to assess the efficacy of ADX-038 compared with placebo in participants with GA secondary to AMD. Safety, pharmacokinetics (PK), and pharmacodynamics (PD) will also be assessed.

Interventions

  • DRUG Placebo
  • DRUG ADX-038

Study Locations (17)

Texas

  • ADARx Clinical Site — McAllen
  • ADARx Clinical Site — Round Rock
  • ADARx Clinical Site — San Antonio
  • ADARx Clinical Site — The Woodlands

California

  • ADARx Clinical Site — Beverly Hills
  • ADARx Clinical Site — Huntington Beach
  • ADARx Clinical Site — Poway

Arizona

  • ADARx Clinical Site — Gilbert
  • ADARx Clinical Site — Phoenix

New South Wales

  • ADARx Clinical Site — Albury
  • ADARx Clinical Site — Parramatta

Ontario

  • ADARx Clinical Site — Ottawa
  • ADARx Clinical Site — Toronto

Florida

  • ADARx Clinical Site — Orlando

Maryland

  • ADARx Clinical Site — Hagerstown

Pennsylvania

  • ADARx Clinical Site — Erie

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2025-11-10
Est. Completion 2027-12
Phase Phase 2

Sponsor

ADARx Pharmaceuticals

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06990269

The ClinicalTrials.gov registry entry for NCT06990269 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ADARx Pharmaceuticals, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Geographic Atrophy Secondary to Age-related Macular Degeneration appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06990269 reports 17 study locations spanning 9 distinct geographic areas — top geographies include Texas, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06990269 about?

NCT06990269 is a clinical study titled "Phase 2 Study of ADX-038 in Participants With Geographic Atrophy". Phase 2 study is designed to assess the efficacy of ADX-038 compared with placebo in participants with GA secondary to AMD. Safety, pharmacokinetics (PK), and pharmacodynamics (PD) will also be assessed.

What is the current status of trial NCT06990269?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-11-10. Estimated completion is 2027-12.

What conditions does trial NCT06990269 study?

This clinical trial studies the following conditions: Geographic Atrophy Secondary to Age-related Macular Degeneration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06990269?

The interventions under investigation include: Placebo (DRUG), ADX-038 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06990269?

This trial is sponsored by ADARx Pharmaceuticals, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06990269 being conducted?

This trial has 17 study locations across Arizona, California, Florida, Maryland, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial