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NCT07209683 · ClinicalTrials.gov registry record · NA
The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults
A NA study of Cognition and Brain Aging, sponsored by University of Oklahoma.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07209683: Recruiting NA study of Cognition and Brain Aging, sponsored by University of Oklahoma.
NCT07209683 is a NA study of Cognition and Brain Aging that is actively recruiting participants, run by University of Oklahoma. The registered enrollment target is 30 participants, below the 171-participant average among 35 other Cognition trials with a reported enrollment target (82% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07209683, a NA study of Cognition and Brain Aging, is actively recruiting participants, sponsored by University of Oklahoma.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in older adults. The main questions it aims to answer are: * Does tPBM enhance neurovascular coupling responses during memory and finger tapping tasks? * Are these improvements linked to better cognitive performance and lower levels of brain inflammation and oxidative stress? Researchers will compare an active tPBM treatment arm to a sham treatment arm to see if tPBM leads to measurable improvements in brain activity and cognitive function compared to no active stimulation. Participants will: * Receive either active tPBM or sham stimulation sessions for 4 weeks, every other day using a portable intervention device. * Complete questionnaires and an iPAD-based cognitive testing protocol * Complete memory and motor tasks while their brain activity is measured using non-invasive techniques: simultaneous functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), transcranial doppler (TCD) flowmetry. * Retinal vessel reactivity will be measured during flickering light stimulus using a special camera (dynamic vessel analysis, DVA). * Provide blood samples to test for biomarkers of inflammation, oxidative stress and brain cell damage.
Primary Outcome
Cognitive performance will be assessed by using the following batteries of the NIH Toolbox: 1) Dimensional Change Card Sort \[executive function\]; 2) Pattern Comparison Processing Speed; 3) List Sorting Working Memory; 4) Flanker Inhibitory Control and Attention; 5) Picture Sequencing Memory and/or 6) Oral Symbol Digit Test.
Conditions Studied
Interventions
- DEVICE transcranial photobiomodulation
Study Locations (1)
Oklahoma
- University of Oklahoma Health Campus - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-10-01 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT07209683 shows while recruiting
NCT07209683 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 171-participant average among 35 other Cognition trials with a reported enrollment target (82% lower).
The record links to 5 conditions, with Cognition appearing as the primary indexed condition, and to 1 intervention - of which transcranial photobiomodulation is the first listed.
NCT07209683 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT07209683 about?
NCT07209683 is a clinical study titled "The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults". The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in older adults. The main questions it aims ...
What is the current status of trial NCT07209683?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-10-01. Estimated completion is 2026-12-31.
What conditions does trial NCT07209683 study?
This clinical trial studies the following conditions: Cognition, Brain Aging, Neurovascular Control, Neurovascular Coupling Mechanism and Cognitive Function, Brain Activity.
What interventions are being tested in trial NCT07209683?
The interventions under investigation include: transcranial photobiomodulation (DEVICE).
Who is sponsoring clinical trial NCT07209683?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07209683 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07209683's enrollment target sits among peer trials
30 31st of 35 higher than 4 of 35 other Cognition trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cognition trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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