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NCT07176390 · ClinicalTrials.gov registry record · Phase 2
A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)
A Phase 2 study of Arthritis, Rheumatoid, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 182
- Enrollment target
- 20
- Study locations
NCT07176390 is a Phase 2 study of Arthritis, Rheumatoid that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 182 participants, below the 634-participant average among 27 other Arthritis, Rheumatoid trials with a reported enrollment target (71% lower). The trial reports 20 study locations across 13 states.
The verdict
NCT07176390, a Phase 2 study of Arthritis, Rheumatoid, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 182 participants
- Enrollment target
- 20
- Study locations
Study Summary
Researchers are looking for new ways to treat rheumatoid arthritis (RA). Methotrexate (MTX) is a standard (usual) treatment for RA. However, MTX and other current treatments may not work well to treat RA symptoms for many people. This study will help find out if a study medicine called tulisokibart can treat symptoms of active RA in people who are taking MTX. In this study, researchers will look at different doses of tulisokibart. Researchers want to learn if at least one of the study doses of tulisokibart works better than a placebo to lessen RA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Methotrexate
- DRUG Tulisokibart
Study Locations (20)
Texas
- Rheumatology Associates ( Site 1026) - Arlington
- Epic Medical Research ( Site 1004) - Red Oak
- Advanced Rheumatology of Houston - Woodlands ( Site 1000) - The Woodlands
Arizona
- Arizona Arthritis & Rheumatology Associates, P.C. ( Site 1018) - Glendale
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa ( Site 1033) - Mesa
Florida
- Sweet Hope Research Specialty, Inc ( Site 1015) - Hialeah
- HMD Research LLC ( Site 1016) - Orlando
Pennsylvania
- altoona center for clinical research ( Site 1005) - Duncansville
- Rheumatology Specialty Center ( Site 1030) - Willow Grove
Quebec
- CIUSSS de l'Estrie - CHUS, Hotel-Dieu de Sherbrooke ( Site 1106) - Sherbrooke
- Centre de Recherche Musculo-Squelettique ( Site 1101) - Trois-Rivières
Region M. de Santiago
- Centro de Estudios GyC ( Site 1206) - Santiago
- Clinica Dermacross ( Site 1203) - Santiago
California
- Arthritis & Osteoporosis Medical Center - La Palma ( Site 1024) - La Palma
Colorado
- Tekton Research, LLC. ( Site 1008) - Fort Collins
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 182 participants |
| Start Date | 2025-10-08 |
| Est. Completion | 2029-09-03 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07176390
The ClinicalTrials.gov registry entry for NCT07176390 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 182 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 634-participant average among 27 other Arthritis, Rheumatoid trials with a reported enrollment target (71% lower). The listed sponsor is Merck Sharp & Dohme, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Arthritis, Rheumatoid appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT07176390 reports 20 study locations spanning 13 distinct geographic areas - top geographies include Texas, Arizona, Florida.
Frequently Asked Questions
What is clinical trial NCT07176390 about?
NCT07176390 is a clinical study titled "A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)". Researchers are looking for new ways to treat rheumatoid arthritis (RA). Methotrexate (MTX) is a standard (usual) treatment for RA. However, MTX and other current treatments may not work well to treat RA symptoms for many people. This study will help find out if a study medicine called tulisokibart...
What is the current status of trial NCT07176390?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 182 participants. The study started on 2025-10-08. Estimated completion is 2029-09-03.
What conditions does trial NCT07176390 study?
This clinical trial studies the following conditions: Arthritis, Rheumatoid.
What interventions are being tested in trial NCT07176390?
The interventions under investigation include: Placebo (DRUG), Methotrexate (DRUG), Tulisokibart (DRUG).
Who is sponsoring clinical trial NCT07176390?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07176390 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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