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NCT07171619 · ClinicalTrials.gov registry record · Phase 1
Evaluate the Effects of Famotidine or Rabeprazole on the PK of Nirogacestat
A Phase 1 study of Healthy, sponsored by SpringWorks Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT07171619: Recruiting Phase 1 study of Healthy, sponsored by SpringWorks Therapeutics.
NCT07171619 is a Phase 1 study of Healthy that is actively recruiting participants, run by SpringWorks Therapeutics. The registered enrollment target is 24 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07171619, a Phase 1 study of Healthy, is actively recruiting participants, sponsored by SpringWorks Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will evaluate the effects of the H2 blocker famotidine or the PPI rabeprazole on the PK of nirogacestat in healthy male participants
Primary Outcome
Serum AUCinf of nirogacestat.
Conditions Studied
Interventions
- DRUG Nirogacestat
- DRUG Nirogacestat and Famotidine
- DRUG Nirogacestat and Rabeprazole
Study Locations (1)
Ohio
- Medpace - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-09-09 |
| Est. Completion | 2025-11 |
| Phase | Phase 1 |
What NCT07171619 shows while recruiting
NCT07171619 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Nirogacestat is the first listed.
NCT07171619 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07171619 about?
NCT07171619 is a clinical study titled "Evaluate the Effects of Famotidine or Rabeprazole on the PK of Nirogacestat". This study will evaluate the effects of the H2 blocker famotidine or the PPI rabeprazole on the PK of nirogacestat in healthy male participants
What is the current status of trial NCT07171619?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-09-09. Estimated completion is 2025-11.
What conditions does trial NCT07171619 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT07171619?
The interventions under investigation include: Nirogacestat (DRUG), Nirogacestat and Famotidine (DRUG), Nirogacestat and Rabeprazole (DRUG).
Who is sponsoring clinical trial NCT07171619?
This trial is sponsored by SpringWorks Therapeutics, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07171619 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07171619's enrollment target sits among peer trials
24 791st of 1090 higher than 254 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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