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NCT07091500 · ClinicalTrials.gov registry record · NA
Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity
A NA study of Obesity and Skeletal Muscle, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07091500: Recruiting NA study of Obesity and Skeletal Muscle, sponsored by Washington University School of Medicine.
NCT07091500 is a NA study of Obesity and Skeletal Muscle that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 40 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07091500, a NA study of Obesity and Skeletal Muscle, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The use of glucagon-like peptide receptor agonists (GLP-1 RAs) may have clinically important effects on skeletal muscle mass (SMM), and physical function. The effects of exercise training in conjunction with GLP-1 RA therapy on these outcomes has not been studied. Additionally, most people treated with GLP-1-based weight loss medications stop taking these medications within 1 year of initiating treatment. This is an important clinical concern because weight regain can occur after weight loss pharmacotherapy is stopped and the impact of stopping GLP-1 RA therapy on physical and metabolic function has not been studied. In this study, the investigators will conduct a 2-year randomized clinical trial to evaluate body composition, muscle physical and metabolic function, and muscle strength in response to GLP-1 RA therapy, with or without exercise training, and subsequent treatment cessation on muscle-related outcomes.
Primary Outcome
Score on the Modified Physical Performance Test
Conditions Studied
Interventions
- DRUG Semaglutide
- BEHAVIORAL Exercise training
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-08-11 |
| Est. Completion | 2029-08-01 |
| Phase | NA |
What NCT07091500 shows while recruiting
NCT07091500 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Semaglutide is the first listed.
NCT07091500 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT07091500 about?
NCT07091500 is a clinical study titled "Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity". The use of glucagon-like peptide receptor agonists (GLP-1 RAs) may have clinically important effects on skeletal muscle mass (SMM), and physical function. The effects of exercise training in conjunction with GLP-1 RA therapy on these outcomes has not been studied. Additionally, most people treated w...
What is the current status of trial NCT07091500?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-08-11. Estimated completion is 2029-08-01.
What conditions does trial NCT07091500 study?
This clinical trial studies the following conditions: Obesity, Skeletal Muscle.
What interventions are being tested in trial NCT07091500?
The interventions under investigation include: Semaglutide (DRUG), Exercise training (BEHAVIORAL).
Who is sponsoring clinical trial NCT07091500?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07091500 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07091500's enrollment target sits among peer trials
40 778th of 1053 higher than 249 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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