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ACTIVE NOT RECRUITING Phase 2

ORKA-001 Versus Placebo in Patients With Moderate-to-Severe Plaque Psoriasis

NCT07090330 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, randomized, double-blinded, placebo-controlled, proof-of-concept study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of ORKA-001 in adult participants with moderate-to-severe plaque psoriasis.

Conditions Studied

Interventions

  • OTHER Placebo
  • DRUG ORKA-001 Induction Dose
  • DRUG ORKA-001 Maintenance Dose

Study Locations (20)

California

  • Oruka Therapeutics Investigative Site — Fountain Valley
  • Oruka Therapeutics Investigative Site — Los Angeles
  • Oruka Therapeutics Investigative Site — San Diego
  • Oruka Therapeutics Investigative Site — Santa Ana
  • Oruka Therapeutics Investigative Site — Santa Monica

New York

  • Oruka Therapeutics Investigative Site — New York
  • Oruka Therapeutics Investigative Site — New York

Alberta

  • Oruka Therapeutics Investigative Site — Edmonton
  • Oruka Therapeutics Investigative Site — Edmonton

Connecticut

  • Oruka Therapeutics Investigative Site — Cromwell

Florida

  • Oruka Therapeutics Investigative Site — Coral Gables

Illinois

  • Oruka Therapeutics Investigative Site — Rolling Meadows

Kentucky

  • Oruka Therapeutics Investigative Site — Bowling Green

Maryland

  • Oruka Therapeutics Investigative Site — Rockville

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2025-07-18
Est. Completion 2027-05
Phase Phase 2

Sponsor

Oruka Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07090330

The ClinicalTrials.gov registry entry for NCT07090330 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Oruka Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Plaque Psoriasis appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07090330 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, New York, Alberta. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07090330 about?

NCT07090330 is a clinical study titled "ORKA-001 Versus Placebo in Patients With Moderate-to-Severe Plaque Psoriasis". This is a multicenter, randomized, double-blinded, placebo-controlled, proof-of-concept study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of ORKA-001 in adult participants with moderate-to-severe plaque psoriasis.

What is the current status of trial NCT07090330?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2025-07-18. Estimated completion is 2027-05.

What conditions does trial NCT07090330 study?

This clinical trial studies the following conditions: Plaque Psoriasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07090330?

The interventions under investigation include: Placebo (OTHER), ORKA-001 Induction Dose (DRUG), ORKA-001 Maintenance Dose (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07090330?

This trial is sponsored by Oruka Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07090330 being conducted?

This trial has 20 study locations across California, Connecticut, Florida, Illinois, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial