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NCT07031336 · ClinicalTrials.gov registry record · NA
Photon-counting CT in Chest Imaging
A NA study of COPD (Chronic Obstructive Pulmonary Disease), sponsored by Duke University.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07031336: Recruiting NA study of COPD (Chronic Obstructive Pulmonary Disease), sponsored by Duke University.
NCT07031336 is a NA study of COPD (Chronic Obstructive Pulmonary Disease) that is actively recruiting participants, run by Duke University. The registered enrollment target is 40 participants, below the 731-participant average among 9 other COPD (Chronic Obstructive Pulmonary Disease) trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07031336, a NA study of COPD (Chronic Obstructive Pulmonary Disease), is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects. The goal is to establish acquisition protocols for PCCT scans with proper post-processing (e.g., reconstruction parameters and harmonization techniques) that enable reproducible measurements of emphysema metrics (e.g., Perc15, LAA-950, HU accuracy) and airways (Pi10, WA%) in the lungs. Study activities and population group: The study will recruit subjects from a current study at Duke (COPDGene Phase 4, Pro00113442). Here are the aims: * The research team will request consent from participants to acquire PCCT scans at their Phase 4 COPDGene visit. Scans will be performed using a PCCT-specific protocol. * Reconstruct the PCCT images with multiple post-acquisition parameter settings. Apply harmonization techniques that are recently developed by the investigators of this study. Data analysis: * Identify the reconstruction and harmonization conditions that enable reproducible measurements of emphysema metrics (perc15, LAA-950, HU accuracy) and airways (Pi10, WA%), when compared to the counterpart EICT scans. * Demonstrate the non-inferiority and potentially improved capabilities of PCCT scans in cross-sectional and longitudinal studies. Risk/safety issues: The participants are asked to get an additional CT scan with a PCCT scanner at their COPDGene Phase 4 visit. This additional CT scan will be done using an inspiratory chest protocol with a total of 3 mGy (\~1.5 mSv) radiation dose. This is roughly equivalent of 6 month of background radiation. Women who are pregnant will not have a chest CT scan done until they are confirmed to be not pregnant.
Primary Outcome
Perc15 will be measured from CT images, and its reproducibility will be quantified. The reproducibility of the measurements is defined as the least significant difference between two consecutive measurements across imaging conditions using the within-subject standard deviation method. The 95% confidence interval for reproducibility will be generated using a bootstrapping method with 5000 samples.
Conditions Studied
Interventions
- DEVICE Photon-counting CT
- DEVICE Energy-integrating CT
Study Locations (1)
North Carolina
- Duke University Hospital - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-11-14 |
| Est. Completion | 2026-05-12 |
| Phase | NA |
What NCT07031336 shows while recruiting
NCT07031336 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 731-participant average among 9 other COPD (Chronic Obstructive Pulmonary Disease) trials with a reported enrollment target (95% lower).
The record links to 1 condition, with COPD (Chronic Obstructive Pulmonary Disease) appearing as the primary indexed condition, and to 2 interventions - of which Photon-counting CT is the first listed.
NCT07031336 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07031336 about?
NCT07031336 is a clinical study titled "Photon-counting CT in Chest Imaging". Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects. The goal is to establish acquisition protocols for PCCT scans with proper post-processing (e.g., reconstruction parameters and harmonization techniques) that...
What is the current status of trial NCT07031336?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-11-14. Estimated completion is 2026-05-12.
What conditions does trial NCT07031336 study?
This clinical trial studies the following conditions: COPD (Chronic Obstructive Pulmonary Disease).
What interventions are being tested in trial NCT07031336?
The interventions under investigation include: Photon-counting CT (DEVICE), Energy-integrating CT (DEVICE).
Who is sponsoring clinical trial NCT07031336?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07031336 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07031336's enrollment target sits among peer trials
40 9th of 9 higher than 1 of 9 other COPD (Chronic Obstructive Pulmonary Disease) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COPD (Chronic Obstructive Pulmonary Disease) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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