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NCT07031336 · ClinicalTrials.gov registry record · NA
Photon-counting CT in Chest Imaging
A NA study of COPD (Chronic Obstructive Pulmonary Disease), sponsored by Duke University.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07031336 is a NA study of COPD (Chronic Obstructive Pulmonary Disease) that is actively recruiting participants, run by Duke University. The registered enrollment target is 40 participants, below the 731-participant average among 9 other COPD (Chronic Obstructive Pulmonary Disease) trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07031336, a NA study of COPD (Chronic Obstructive Pulmonary Disease), is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects. The goal is to establish acquisition protocols for PCCT scans with proper post-processing (e.g., reconstruction parameters and harmonization techniques) that enable reproducible measurements of emphysema metrics (e.g., Perc15, LAA-950, HU accuracy) and airways (Pi10, WA%) in the lungs. Study activities and population group: The study will recruit subjects from a current study at Duke (COPDGene Phase 4, Pro00113442). Here are the aims: * The research team will request consent from participants to acquire PCCT scans at their Phase 4 COPDGene visit. Scans will be performed using a PCCT-specific protocol. * Reconstruct the PCCT images with multiple post-acquisition parameter settings. Apply harmonization techniques that are recently developed by the investigators of this study. Data analysis: * Identify the reconstruction and harmonization conditions that enable reproducible measurements of emphysema metrics (perc15, LAA-950, HU accuracy) and airways (Pi10, WA%), when compared to the counterpart EICT scans. * Demonstrate the non-inferiority and potentially improved capabilities of PCCT scans in cross-sectional and longitudinal studies. Risk/safety issues: The participants are asked to get an additional CT scan with a PCCT scanner at their COPDGene Phase 4 visit. This additional CT scan will be done using an inspiratory chest protocol with a total of 3 mGy (\~1.5 mSv) radiation dose. This is roughly equivalent of 6 month of background radiation. Women who are pregnant will not have a chest CT scan done until they are confirmed to be not pregnant.
Conditions Studied
Interventions
- DEVICE Photon-counting CT
- DEVICE Energy-integrating CT
Study Locations (1)
North Carolina
- Duke University Hospital - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-11-14 |
| Est. Completion | 2026-05-12 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07031336
The ClinicalTrials.gov registry entry for NCT07031336 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 731-participant average among 9 other COPD (Chronic Obstructive Pulmonary Disease) trials with a reported enrollment target (95% lower). The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with COPD (Chronic Obstructive Pulmonary Disease) appearing as the primary indexed condition, and to 2 interventions - of which Photon-counting CT is the first listed.
NCT07031336 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT07031336 about?
NCT07031336 is a clinical study titled "Photon-counting CT in Chest Imaging". Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects. The goal is to establish acquisition protocols for PCCT scans with proper post-processing (e.g., reconstruction parameters and harmonization techniques) that...
What is the current status of trial NCT07031336?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-11-14. Estimated completion is 2026-05-12.
What conditions does trial NCT07031336 study?
This clinical trial studies the following conditions: COPD (Chronic Obstructive Pulmonary Disease).
What interventions are being tested in trial NCT07031336?
The interventions under investigation include: Photon-counting CT (DEVICE), Energy-integrating CT (DEVICE).
Who is sponsoring clinical trial NCT07031336?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07031336 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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