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RECRUITING Phase 1

A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate Cancer

NCT06990880 · View on ClinicalTrials.gov ↗

Study Summary

The goal of the study is to evaluate how safe and how well the body handles GSK5458514 when administered in participants with prostate cancer. The study will be conducted in two parts - Part 1 (dose escalation phase) and Part 2 (dose expansion phase).

Conditions Studied

Interventions

  • DRUG GSK5458514

Study Locations (5)

Other

  • GSK Investigational Site — Tokyo
  • GSK Investigational Site — Tokyo

Colorado

  • GSK Investigational Site — Denver

Tennessee

  • GSK Investigational Site — Nashville

Quebec

  • GSK Investigational Site — Montreal

Trial Details

FieldValue
Enrollment Target 85 participants
Start Date 2025-06-12
Est. Completion 2028-08-09
Phase Phase 1

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06990880

The ClinicalTrials.gov registry entry for NCT06990880 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 85 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neoplasms, Prostate appearing as the primary indexed condition, and to 1 intervention — of which GSK5458514 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06990880 reports 5 study locations spanning 4 distinct geographic areas — top geographies include Other, Colorado, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06990880 about?

NCT06990880 is a clinical study titled "A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate Cancer". The goal of the study is to evaluate how safe and how well the body handles GSK5458514 when administered in participants with prostate cancer. The study will be conducted in two parts - Part 1 (dose escalation phase) and Part 2 (dose expansion phase).

What is the current status of trial NCT06990880?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 85 participants. The study started on 2025-06-12. Estimated completion is 2028-08-09.

What conditions does trial NCT06990880 study?

This clinical trial studies the following conditions: Neoplasms, Prostate. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06990880?

The interventions under investigation include: GSK5458514 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06990880?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06990880 being conducted?

This trial has 5 study locations across Colorado, Tennessee, Quebec. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial