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NCT06974773 · ClinicalTrials.gov registry record · NA
Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
A NA study of Endometriosis, sponsored by Samphire Group.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT06974773: Recruiting NA study of Endometriosis, sponsored by Samphire Group.
NCT06974773 is a NA study of Endometriosis that is actively recruiting participants, run by Samphire Group. The registered enrollment target is 120 participants, below the 262-participant average among 48 other Endometriosis trials with a reported enrollment target (54% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06974773, a NA study of Endometriosis, is actively recruiting participants, sponsored by Samphire Group.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis. The study also aims to assess the safety and usability of the device when used at home over several months. The main questions it aims to answer are: 1. Does at-home transcranial direct current stimulation (tDCS) reduce daily pain intensity in women with endometriosis? 2. Does the device also improve mood and sleep quality? Researchers will compare two groups-one receiving active brain stimulation and one receiving a sham (placebo) stimulation-to see if the active device provides greater improvements in symptoms. Participants will: 1. Use the NettleEndo device at home for 20 minutes per session, five times per week for 12 weeks 2. Be randomly assigned to receive either real or sham stimulation through the device 3. Complete daily and weekly symptom ratings through a mobile app 4. Be followed for 90 days after completing the intervention to monitor longer-term effects All activities are completed remotely using a smartphone app. Participants can contact the study team with questions at any time. The study is double-blind, meaning neither participants nor the researchers assessing outcomes will know who received active or sham treatment until the end of the trial.
Primary Outcome
Average change from baseline in daily self-reported pain intensity related to endometriosis, using a 0-10 Numerical Rating Scale (NRS). This will be measured separately for dysmenorrhea (Dysmenorrhea NRS; DYS NRS) and non-menstrual pelvic pain (Non-Menstrual Pelvic Pain; NMPP NRS). Collected via mobile app. A decrease in NRS, NMPP NRS and DYS NRS scores indicate a better outcome, as it reflects reduced pain intensity.
Conditions Studied
Interventions
- DEVICE NettleEndo
- DEVICE Sham NettleEndo Device
Study Locations (1)
California
- Alethios, Inc. - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2025-12-04 |
| Est. Completion | 2026-08-01 |
| Phase | NA |
What NCT06974773 shows while recruiting
NCT06974773 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 262-participant average among 48 other Endometriosis trials with a reported enrollment target (54% lower).
The record links to 1 condition, with Endometriosis appearing as the primary indexed condition, and to 2 interventions - of which NettleEndo is the first listed.
NCT06974773 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06974773 about?
NCT06974773 is a clinical study titled "Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups". The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis. The study also aims to assess the safety and usability of the device when used at home over several months. The main...
What is the current status of trial NCT06974773?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2025-12-04. Estimated completion is 2026-08-01.
What conditions does trial NCT06974773 study?
This clinical trial studies the following conditions: Endometriosis.
What interventions are being tested in trial NCT06974773?
The interventions under investigation include: NettleEndo (DEVICE), Sham NettleEndo Device (DEVICE).
Who is sponsoring clinical trial NCT06974773?
This trial is sponsored by Samphire Group, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06974773 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Endometriosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06974773's enrollment target sits among peer trials
120 18th of 48 higher than 27 of 48 other Endometriosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Endometriosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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