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NCT06974357 · ClinicalTrials.gov registry record · NA
Evaluation of Genetic Abnormalities Amongst Calcium Phosphate Stone Formers
A NA study of Nephrolithiasis, sponsored by Ryan L Steinberg.
- Recruiting
- Registry status
- NA
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT06974357: Recruiting NA study of Nephrolithiasis, sponsored by Ryan L Steinberg.
NCT06974357 is a NA study of Nephrolithiasis that is actively recruiting participants, run by Ryan L Steinberg. The registered enrollment target is 15 participants, below the 123-participant average among 16 other Nephrolithiasis trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06974357, a NA study of Nephrolithiasis, is actively recruiting participants, sponsored by Ryan L Steinberg.
- RECRUITING
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
Kidney stones continue to affect more and more people in the United States with the most recent estimate being 1 in 9 people will develop a stone in their life. While family history is a known risk factor for stone disease, it remains unclear whether this is related to learned dietary habits or a truly inheritable genetic condition. Known inheritable genetic conditions linked to stone formation are uncommon, and thus, routine genetic testing is not currently recommended by any major urologic organizations. Patients who form calcium phosphate predominant stones, a less common type of stone composition, tend to have alkaline urine pH which suggests that the kidneys are unable to rid the body of acid. Management of such patients for stone prevention can be difficult. The Iowa Institute for Human Genomics is one of only a handful of commercial labs which offers genetic testing for stone disease. The aim of this study is to assess the rate of genetic abnormalities amongst calcium phosphate predominant stone formers with alkaline urine. To this end, the investigators plan to enroll calcium phosphate predominant stone forming patients with alkaline urine on 24 hour urine collection who obtain their health care at UIHC to undergo free genetic testing via blood draw to assess for genetic abnormalities. The investigators will also collect information already available in the subject's chart to assess for other patterns between blood and urine tests and any genetic variants.
Primary Outcome
assess the overall rate of genetic variants among the stone population
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Genetic testing
Study Locations (1)
Iowa
- University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2025-03-15 |
| Est. Completion | 2027-03-01 |
| Phase | NA |
What NCT06974357 shows while recruiting
NCT06974357 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 123-participant average among 16 other Nephrolithiasis trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Nephrolithiasis appearing as the primary indexed condition, and to 1 intervention - of which Genetic testing is the first listed.
NCT06974357 reports a single indexed study location in Iowa.
Frequently Asked Questions
What is clinical trial NCT06974357 about?
NCT06974357 is a clinical study titled "Evaluation of Genetic Abnormalities Amongst Calcium Phosphate Stone Formers". Kidney stones continue to affect more and more people in the United States with the most recent estimate being 1 in 9 people will develop a stone in their life. While family history is a known risk factor for stone disease, it remains unclear whether this is related to learned dietary habits or a tr...
What is the current status of trial NCT06974357?
This trial is currently recruiting. It is a NA study. The enrollment target is 15 participants. The study started on 2025-03-15. Estimated completion is 2027-03-01.
What conditions does trial NCT06974357 study?
This clinical trial studies the following conditions: Nephrolithiasis.
What interventions are being tested in trial NCT06974357?
The interventions under investigation include: Genetic testing (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06974357?
This trial is sponsored by Ryan L Steinberg, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06974357 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06974357's enrollment target sits among peer trials
15 16th of 16 higher than 1 of 16 other Nephrolithiasis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Nephrolithiasis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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