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NCT06958328 · ClinicalTrials.gov registry record · Phase 3

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

A Phase 3 study of Stage IV Pancreatic Cancer AJCC v8 and Stage III Pancreatic Cancer AJCC v8, sponsored by NRG Oncology.

Recruiting
Registry status
Phase 3
Development phase
356
Enrollment target
20
Study locations

NCT06958328 is a Phase 3 study of Stage IV Pancreatic Cancer AJCC v8 and Stage III Pancreatic Cancer AJCC v8 that is actively recruiting participants, run by NRG Oncology. The registered enrollment target is 356 participants, above the 77-participant average among 31 other Stage IV Pancreatic Cancer AJCC v8 trials with a reported enrollment target (362% higher). The trial reports 20 study locations across 3 states.

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The verdict

NCT06958328, a Phase 3 study of Stage IV Pancreatic Cancer AJCC v8 and Stage III Pancreatic Cancer AJCC v8, is actively recruiting participants, sponsored by NRG Oncology.

RECRUITING
Registry status
Phase 3
Development phase
356 participants
Enrollment target
20
Study locations

Study Summary

This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-6 months of chemotherapy. Usual care options include additional chemotherapy, observation, or standard lower-dose radiation therapy. These treatments may delay tumor growth but have not been shown to improve survival. Radiation therapy uses high energy X-rays to kill cancer cells and shrink tumors. Dose-escalated radiation therapy involves the precise delivery of higher doses to the tumor, often over a shorter period of time. This trial assesses whether using dose-escalated radiation therapy can prolong survival.

Conditions Studied

Stage IV Pancreatic Cancer AJCC v8 Stage III Pancreatic Cancer AJCC v8 Stage II Pancreatic Cancer AJCC v8 Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

Interventions

  • PROCEDURE Biospecimen Collection
  • PROCEDURE Computed Tomography
  • DRUG Capecitabine
  • PROCEDURE Biopsy Procedure
  • RADIATION Dose-escalated Radiation Therapy

Study Locations (20)

California

  • AIS Cancer Center at San Joaquin Community Hospital - Bakersfield
  • Alta Bates Summit Medical Center-Herrick Campus - Berkeley
  • Mills-Peninsula Medical Center - Burlingame
  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park - Cameron Park
  • Palo Alto Medical Foundation-Fremont - Fremont
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care - Irvine
  • UC San Diego Moores Cancer Center - La Jolla
  • Memorial Medical Center - Modesto
  • Palo Alto Medical Foundation-Camino Division - Mountain View
  • UC Irvine Health/Chao Family Comprehensive Cancer Center - Orange
  • Palo Alto Medical Foundation Health Care - Palo Alto
  • Stanford Cancer Institute Palo Alto - Palo Alto

Arizona

  • Banner MD Anderson Cancer Center - Gilbert
  • Arizona Center for Cancer Care - Gilbert - Gilbert
  • Arizona Center for Cancer Care-Peoria - Peoria
  • Arizona Center for Cancer Care - Phoenix - Phoenix
  • Arizona Center for Cancer Care - Scottsdale - Scottsdale
  • Arizona Center for Cancer Care-Surprise - Surprise
  • Arizona Center for Cancer Care - Tempe

Arkansas

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro - Jonesboro

Trial Details

FieldValue
Enrollment Target 356 participants
Start Date 2025-08-21
Est. Completion 2030-10-21
Phase Phase 3

Sponsor

NRG Oncology

64 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06958328

The ClinicalTrials.gov registry entry for NCT06958328 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 356 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 77-participant average among 31 other Stage IV Pancreatic Cancer AJCC v8 trials with a reported enrollment target (362% higher). The listed sponsor is NRG Oncology, which has 64 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Stage IV Pancreatic Cancer AJCC v8 appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.

NCT06958328 reports 20 study locations spanning 3 distinct geographic areas - top geographies include California, Arizona, Arkansas.

Frequently Asked Questions

What is clinical trial NCT06958328 about?

NCT06958328 is a clinical study titled "Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer". This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-6 months of chemotherapy. Usual care options include additional chemotherapy, observation, or stan...

What is the current status of trial NCT06958328?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 356 participants. The study started on 2025-08-21. Estimated completion is 2030-10-21.

What conditions does trial NCT06958328 study?

This clinical trial studies the following conditions: Stage IV Pancreatic Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8, Stage II Pancreatic Cancer AJCC v8, Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma.

What interventions are being tested in trial NCT06958328?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Computed Tomography (PROCEDURE), Capecitabine (DRUG), Biopsy Procedure (PROCEDURE), Dose-escalated Radiation Therapy (RADIATION).

Who is sponsoring clinical trial NCT06958328?

This trial is sponsored by NRG Oncology, which has 64 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06958328 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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