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NCT06938841 · ClinicalTrials.gov registry record · NA
Maintenance rTMS for Depression (Maitr-De)
A NA study of Major Depressive Disorder and Treatment-Resistant Depression, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- NA
- Development phase
- 75
- Enrollment target
- 3
- Study locations
NCT06938841: Recruiting NA study of Major Depressive Disorder and Treatment-Resistant Depression, sponsored by University of California, San Diego.
NCT06938841 is a NA study of Major Depressive Disorder and Treatment-Resistant Depression that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 75 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (80% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06938841, a NA study of Major Depressive Disorder and Treatment-Resistant Depression, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- NA
- Development phase
- 75 participants
- Enrollment target
- 3
- Study locations
Study Summary
Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS in individuals with TRD who have previously responded to an acute course of rTMS. In the R61 phase of the study, we will recruit 75 participants across three study sites, the University of California San Diego, Weill Cornell Medicine, and Australian National University, into a double-blind, three-arm maintenance treatment trial. In this trial, participants will be randomized to receive either standard maintenance rTMS, clustered maintenance rTMS, or sham maintenance rTMS for a duration of 6 months. Our primary aim is to examine the efficacy of maintenance rTMS on sustaining connectivity between the dorsolateral prefrontal cortex (DLPFC) and subgenual cingulate cortex (SGC) measured through concurrent TMS and electroencephalography (TMS-EEG) at baseline and every six weeks throughout the 6-month treatment period. We will also assess changes in depressive symptom severity using clinical scales, including the Montgomery-Asberg Depression Rating Scale (MADRS) as a secondary outcome measure. It is hypothesized that stimulation with clustered maintenance rTMS will demonstrate superiority in sustaining DLPFC-SGC connectivity compared with standard maintenance rTMS and sham maintenance rTMS
Primary Outcome
Our primary aim is to examine the efficacy of maintenance rTMS on sustaining connectivity between the dorsolateral prefrontal cortex (DLPFC) and subgenual cingulate cortex (SGC) measured through concurrent TMS and electroencephalography (TMS-EEG) at baseline and every six weeks throughout the 6-month treatment period
Conditions Studied
Interventions
- DEVICE Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS:
- DEVICE Transcranial Magnetic Stimulation (TMS) - Clustered maintenance rTMS:
- DEVICE Transcranial Magnetic Stimulation (TMS) -- Sham maintenance rTMS
Study Locations (3)
California
- University of California, San Diego - San Diego
New York
- Weill Cornell Medicine - New York
Australian Capital Territory
- Australian National University - Canberra
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2025-04-01 |
| Est. Completion | 2026-03-31 |
| Phase | NA |
What NCT06938841 shows while recruiting
NCT06938841 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (80% lower).
The record links to 2 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 3 interventions - of which Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS: is the first listed.
NCT06938841 reports a single indexed study location in California, New York, Australian Capital Territory.
Frequently Asked Questions
What is clinical trial NCT06938841 about?
NCT06938841 is a clinical study titled "Maintenance rTMS for Depression (Maitr-De)". Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS ...
What is the current status of trial NCT06938841?
This trial is currently recruiting. It is a NA study. The enrollment target is 75 participants. The study started on 2025-04-01. Estimated completion is 2026-03-31.
What conditions does trial NCT06938841 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Treatment-Resistant Depression.
What interventions are being tested in trial NCT06938841?
The interventions under investigation include: Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS: (DEVICE), Transcranial Magnetic Stimulation (TMS) - Clustered maintenance rTMS: (DEVICE), Transcranial Magnetic Stimulation (TMS) -- Sham maintenance rTMS (DEVICE).
Who is sponsoring clinical trial NCT06938841?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06938841 being conducted?
This trial has 3 study locations across California, New York, Australian Capital Territory. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06938841's enrollment target sits among peer trials
75 150th of 282 higher than 131 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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