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NCT06859424 · ClinicalTrials.gov registry record · Phase 2
A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
A Phase 2 study of Lymphoma and MDS (Myelodysplastic Syndrome), sponsored by Center for International Blood and Marrow Transplant Research.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 358
- Enrollment target
- 13
- Study locations
NCT06859424 is a Phase 2 study of Lymphoma and MDS (Myelodysplastic Syndrome) that is actively recruiting participants, run by Center for International Blood and Marrow Transplant Research. The registered enrollment target is 358 participants, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (26% lower). The trial reports 13 study locations across 12 states.
The verdict
NCT06859424, a Phase 2 study of Lymphoma and MDS (Myelodysplastic Syndrome), is actively recruiting participants, sponsored by Center for International Blood and Marrow Transplant Research.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 358 participants
- Enrollment target
- 13
- Study locations
Study Summary
The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the study participant. The researchers will compare the new drug combination to a standard drug combination. They will also learn about the safety of each drug combination. Participants will: * Receive the standard or new drug combination after transplant * Visit the doctor's office for check-ups and tests after transplant that are routine for most transplant patients * Take surveys about physical and emotional well-being * Give blood and stool samples.
Conditions Studied
Interventions
- DRUG Conditioning Regimen A
- DRUG Conditioning Regimen B
- DRUG Conditioning Regimen C
- DRUG Conditioning Regimen D
- DRUG Conditioning Regimen E
Study Locations (13)
California
- City of Hope - Duarte
- Stanford - Palo Alto
Alabama
- University of Alabama Birmingham - Birmingham
Florida
- University of Miami - Miami
Kansas
- University of Kansas Medical Center - Westwood
Massachusetts
- Dana-Farber Cancer Institute - Boston
Michigan
- Karmanos Cancer Institute - Detroit
New York
- Memorial Sloan Kettering - New York
North Carolina
- University of North Carolina - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 358 participants |
| Start Date | 2025-07-25 |
| Est. Completion | 2028-06 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06859424
The ClinicalTrials.gov registry entry for NCT06859424 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 358 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (26% lower). The listed sponsor is Center for International Blood and Marrow Transplant Research, which has 29 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which Conditioning Regimen A is the first listed.
NCT06859424 reports 13 study locations spanning 12 distinct geographic areas - top geographies include California, Alabama, Florida.
Frequently Asked Questions
What is clinical trial NCT06859424 about?
NCT06859424 is a clinical study titled "A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation". The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the s...
What is the current status of trial NCT06859424?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 358 participants. The study started on 2025-07-25. Estimated completion is 2028-06.
What conditions does trial NCT06859424 study?
This clinical trial studies the following conditions: Lymphoma, MDS (Myelodysplastic Syndrome), Chronic Myelomonocytic Leukemia (CMML), CLL (Chronic Lymphocytic Leukemia), CML (Chronic Myelogenous Leukemia).
What interventions are being tested in trial NCT06859424?
The interventions under investigation include: Conditioning Regimen A (DRUG), Conditioning Regimen B (DRUG), Conditioning Regimen C (DRUG), Conditioning Regimen D (DRUG), Conditioning Regimen E (DRUG).
Who is sponsoring clinical trial NCT06859424?
This trial is sponsored by Center for International Blood and Marrow Transplant Research, which has 29 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06859424 being conducted?
This trial has 13 study locations across Alabama, California, Florida, Kansas, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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