Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
NCT06859424 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the study participant. The researchers will compare the new drug combination to a standard drug combination. They will also learn about the safety of each drug combination. Participants will: * Receive the standard or new drug combination after transplant * Visit the doctor's office for check-ups and tests after transplant that are routine for most transplant patients * Take surveys about physical and emotional well-being * Give blood and stool samples.
Conditions Studied
Interventions
- DRUG Conditioning Regimen A
- DRUG Conditioning Regimen B
- DRUG Conditioning Regimen C
- DRUG Conditioning Regimen D
- DRUG Conditioning Regimen E
Study Locations (13)
California
- City of Hope — Duarte
- Stanford — Palo Alto
Alabama
- University of Alabama Birmingham — Birmingham
Florida
- University of Miami — Miami
Kansas
- University of Kansas Medical Center — Westwood
Massachusetts
- Dana-Farber Cancer Institute — Boston
Michigan
- Karmanos Cancer Institute — Detroit
New York
- Memorial Sloan Kettering — New York
North Carolina
- University of North Carolina — Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 358 participants |
| Start Date | 2025-07-25 |
| Est. Completion | 2028-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06859424
The ClinicalTrials.gov registry entry for NCT06859424 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 358 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Center for International Blood and Marrow Transplant Research, which has 16 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which Conditioning Regimen A is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06859424 reports 13 study locations spanning 12 distinct geographic areas — top geographies include California, Alabama, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06859424 about?
NCT06859424 is a clinical study titled "A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation". The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the s...
What is the current status of trial NCT06859424?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 358 participants. The study started on 2025-07-25. Estimated completion is 2028-06.
What conditions does trial NCT06859424 study?
This clinical trial studies the following conditions: Lymphoma, MDS (Myelodysplastic Syndrome), Chronic Myelomonocytic Leukemia (CMML), CLL (Chronic Lymphocytic Leukemia), Acute Lymphoid Leukemia (ALL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06859424?
The interventions under investigation include: Conditioning Regimen A (DRUG), Conditioning Regimen B (DRUG), Conditioning Regimen C (DRUG), Conditioning Regimen D (DRUG), Conditioning Regimen E (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06859424?
This trial is sponsored by Center for International Blood and Marrow Transplant Research, which has 16 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06859424 being conducted?
This trial has 13 study locations across Alabama, California, Florida, Kansas, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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