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NCT06841627 · ClinicalTrials.gov registry record · NA
Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study
A NA study, sponsored by Edward Via Virginia College of Osteopathic Medicine.
- Completed
- Registry status
- NA
- Development phase
- 31
- Enrollment target
NCT06841627: Completed NA study, sponsored by Edward Via Virginia College of Osteopathic Medicine.
NCT06841627 is a NA study that has completed, run by Edward Via Virginia College of Osteopathic Medicine. The registered enrollment target is 31 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06841627, a NA study, has completed, sponsored by Edward Via Virginia College of Osteopathic Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 31 participants
- Enrollment target
Study Summary
Chronic headaches are associated with changes in brain structure and function that may be associated with increased suffering and disability. Understanding how Osteopathic Manipulative Therapy (OMT) affects these changes would reveal new insight into how the brain processes pain and returns to normal function. Also, demonstrating these changes would provide evidence regarding how OMT causes a reduction in pain and disability, supporting the recommendation for OMT as a primary treatment option for headaches.
Primary Outcome
Structural MRI will assess physical changes in brain anatomy, including differences in the size, shape, or density of specific brain regions. For example, changes in gray matter volume or white matter integrity may indicate neuroplasticity changes response to an OMT. Functional MRI (fMRI) will measure brain activity by detecting changes in blood flow within the central pain network. When a specific brain region becomes more active, it requires more oxygen, which fMRI can detect. This will help d
Interventions
- OTHER Osteopathic Manipulative Therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2025-08-05 |
| Est. Completion | 2026-05-05 |
| Phase | NA |
What the finished NCT06841627 record still lists
NCT06841627 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Osteopathic Manipulative Therapy is the first listed.
NCT06841627 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06841627 about?
NCT06841627 is a clinical study titled "Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study". Chronic headaches are associated with changes in brain structure and function that may be associated with increased suffering and disability. Understanding how Osteopathic Manipulative Therapy (OMT) affects these changes would reveal new insight into how the brain processes pain and returns to norma...
What is the current status of trial NCT06841627?
This trial is currently completed. It is a NA study. The enrollment target is 31 participants. The study started on 2025-08-05. Estimated completion is 2026-05-05.
What interventions are being tested in trial NCT06841627?
The interventions under investigation include: Osteopathic Manipulative Therapy (OTHER).
Who is sponsoring clinical trial NCT06841627?
This trial is sponsored by Edward Via Virginia College of Osteopathic Medicine, which has 19 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06841627's enrollment target sits among peer trials
31 1592nd of 2000 higher than 408 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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